TRAF5
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Official Full Name
TNF receptor-associated factor 5 -
Overview
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF);protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc;fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor;superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor;(TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have;been characterized. -
Synonyms
TRAF5;TNF receptor-associated factor 5;RNF84;RING finger protein 84;MGC:39780
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- SUMO
- Avi
- Fc
Involved Pathway
TRAF5 involved in several pathways and played different roles in them. We selected most pathways TRAF5 participated on our site, such as NF-kappa B signaling pathway,TNF signaling pathway,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TNFSF14,BIRC2,CD14,CXCL12,CCL21B,IL1B,MAP3K7,LYN,ZAP70,BCL2A1 |
| Epstein-Barr virus infection | PSMC5,POLR2A,PSMC1,GTF2B,SPI1,YWHAB,CD44,TYK2,POLR2G,PSMD12 |
| Herpes simplex infection | PKZ,PPP1CAA,MHC1UXA2,FB06F03,MAPK8,EIF2S1B,IL1B,CYCSB,Ccl12,PPP1CB |
| Viral carcinogenesis | KRAS,GTF2H2C_2,YWHAZ,HNRNPK,Casp3,EP300,ATF4,HLA-E,HIST1H2BQ,HLA-G |
| Pathways in cancer | XIAP,CASP8,FGF16,PLCG1,FGF8,RELA,RET,BIRC3,FOS,FGF22 |
| Small cell lung cancer | IKBKG,LAMC2,PTEN,FN1,LAMA4,LAMC1,RXRG,FHIT,PIK3CA,AKT2 |
| TNF signaling pathway | TRAF3,MAP3K5,VCAM1,PIK3R2,PTGS2,ITCH,SELE,CREB5,MAP2K6,TRADD |
Protein Function
TRAF5 has several biochemical functions, for example, protein binding,signal transducer activity,thioesterase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF5 itself. We selected most functions TRAF5 had, and list some proteins which have the same functions with TRAF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | GATAD2AB,MARCH10,RXRB,ZFP346,TRIM8A,NAPEPLD,ZSWIM4,RNPEP,KMT2E,TRIM9 |
| signal transducer activity | OLFR482,TAAR12E,GPR31B,GPR30,TAS2R124,GPR184,MIER1B,CHKA,ACKR3B,CBLC |
| ubiquitin protein ligase binding | CUL3,MAGEA2,TRIM37,TRAF2,AXIN1,C10orf46,NPLOC4,SUMO1,KCNQ3,UBE2G1B |
| protein binding | PRPF8,TRAF3IP2,PIM1,PLEKHA1,RAP1GDS1,MFAP1,DOLK,GRIN3A,C22orf29,NR1H3 |
| thioesterase binding | CALM2,TRAF4,RAC1,ARF6,TRAF3,CALM1,ADRA2A,TRAF1,HAUS7,TRAF6 |
| ubiquitin-protein transferase activity | MKRN1,TRIM71,LRSAM1,DTX3L,RNF135,UBE2D3,RNF187,FBXL14A,BIRC5A,UBE2E3 |
Interacting Protein
TRAF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF5.
TRAF6;NMI;TNFRSF14;SDCBP
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References
- Snell, LM; Lin, GHY; et al. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. IMMUNOLOGICAL REVIEWS 244:197-217(2011).
- Xiang, Q; Chen, L; et al. TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis. ARTHRITIS RESEARCH & THERAPY 15:-(2013).
