TRAF4

  • Official Full Name

    TNF receptor-associated factor 4

  • Overview

    This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

  • Synonyms

    TRAF4;TNF receptor-associated factor 4;CART1;MLN62;RNF83;MLN 62;malignant 62;RING finger protein 83;metastatic lymph node gene 62 protein;tumor necrosis receptor-associated factor 4A;cysteine-rich domain associated with ring and TRAF domain;cys

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRAF4-3387H Recombinant Human TRAF4, GST-tagged E.coli Human GST 35-307AA
TRAF4-558H Recombinant Human TRAF4 Protein, His-tagged E.coli Human His Gln193~Asp444
TRAF4-17289M Recombinant Mouse TRAF4 Protein Mammalian Cells Mouse His
TRAF4-31602TH Recombinant Human TRAF4, His-tagged E.coli Human His 207-406 a.a.
TRAF4-550H Recombinant Human TRAF4 Protein, GST-His-tagged E.coli Human GST&His
TRAF4-820HCL Recombinant Human TRAF4 293 Cell Lysate HEK293 Human Non
TRAF4-6711H Recombinant Human TRAF4 Protein (Gln193-Asp444), His tagged E.coli Human His Gln193-Asp444
TRAF4-9558M Recombinant Mouse TRAF4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TRAF4-9558M-B Recombinant Mouse TRAF4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TRAF4 involved in several pathways and played different roles in them. We selected most pathways TRAF4 participated on our site, such as Pathways in cancer,Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer PIK3R2,PIAS2,MDM2,ITGA2,HSP90AA1,AGTR1A,FGF7,F2RL3,CBLB,NOS2
    Small cell lung cancer APAF1,PTEN,BIRC8,PIK3R2,RELA,PIK3CG,CCNE2,ITGA2,IKBKG,TRP53

    Protein Function

    TRAF4 has several biochemical functions, for example, DNA binding,WW domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF4 itself. We selected most functions TRAF4 had, and list some proteins which have the same functions with TRAF4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding KIF20B,TMEM25,DNAJC10,SIAH1,CYBRD1,RPS2,CSRP2,SMR3B,TSPAN1,SUV420H2
    DNA binding HIST1H2AN,CEBPB,POU3F2A,H3F3B.1,PRDM2,RYBPB,PBX1,MTF1,PCBP3,HER9
    WW domain binding TMEM128,WBP5,TCEAL3,TNK2,TCEAL5,TCEAL6,WBP1,TCEAL8,CDC25C,NFE2
    thioesterase binding ADRA2A,CALM1,TRAF1,RAC1,TRAF6,TRAF5,CALM3,CALM2,ARF6,CALM
    zinc ion binding NEURL1AA,TRIM55A,KDM2BA,RNF4,VPS8,APOBEC1,NR2F1B,FHL3B,ZNF205,TRIM32
    ubiquitin-protein transferase activity BIRC5B,UBR3,PDZRN3,UBR5,CBLB,BTR22,FBXW2,UBE2T,MARCH4,FBXO30B
    protein kinase binding MAPKAP1,PPP1R12B,STAP1,GDF3,PTPN2,NEK9,CCNK,TEX14,VDAC1,IBTK
    ubiquitin protein ligase binding CUL1A,RAD18,YOD1,NLK,TP53,UBE2R2,ARRB1,AXIN2,HSPA1B,TCEB2
    tumor necrosis factor receptor binding TRIM37,TNFSF9,TRAF2,CASP8,TNFSF13,TNFSF4,TRAF1,FASLG,TNFSF11,CD70

    Interacting Protein

    TRAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF4.

    WWP2;BYSL;SMURF1;BCL6B;NPIPA7

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All TRAF4 Products

    Required fields are marked with *

    My Review for All TRAF4 Products

    Required fields are marked with *