TRAF3

  • Official Full Name

    TNF receptor-associated factor 3
  • Overview

    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
  • Synonyms

    TRAF3;TNF receptor-associated factor 3;LAP1;CAP-1;CRAF1;CD40bp;CD40 binding protein;CD40 associated protein 1;LMP1-associated protein 1;CD40 receptor associated factor 1;CAP 1;CD40-binding protein;LAP 1;MIPT3;TRAF3_HUMAN

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Wheat Germ
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • GST
  • DDK
  • Myc
  • His
  • Non
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRAF3-3384H Recombinant Human TRAF3, GST-tagged E.coli Human GST 6-351aa
TRAF3-3385H Recombinant Human TRAF3, GST-tagged Wheat Germ Human GST
TRAF3-3386H Recombinant Human TRAF3, GST-tagged Wheat Germ Human GST
TRAF3-3387H Recombinant Human TRAF3, MYC/DDK-tagged HEK293 Human DDK&Myc
TRAF3-954Z Recombinant Zebrafish TRAF3 Mammalian Cells Zebrafish His
TRAF3-822HCL Recombinant Human TRAF3 293 Cell Lysate HEK293 Human Non
TRAF3-823HCL Recombinant Human TRAF3 293 Cell Lysate HEK293 Human Non
TRAF3-060H Recombinant Human TNF receptor-associated factor 3 Protein, His tagged E.coli Human His 341-568aa
TRAF3-1348H Recombinant Human TRAF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
TRAF3-3617H Recombinant Human TRAF3 protein, His-tagged E.coli Human His 1-568aa
TRAF3-4611H Recombinant Human TRAF3 protein E.coli Human Non 1-568aa
TRAF3-530HF Recombinant Full Length Human TRAF3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 568 amino acids
TRAF3-5407HFL Recombinant Full Length Human TRAF3, Flag-tagged Mammalian Cells Human Flag Full L.
TRAF3-6510H Recombinant Human TRAF3 Protein (Lys6-Lys351), N-His tagged E.coli Human His Lys6-Lys351
Traf3-6618M Recombinant Mouse Traf3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway,Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF signaling pathway CXCL1,MAP2K1,CXCL2,LIF,TNFRSF1A,BCL3,MAPK9,IL15,MAP3K5,LTA
    Pathways in cancer TRAF4,WNT8A,LPAR2,NFKB2,MMP1A,Fzd4,WNT4,HDAC2,EGLN1,CBLB
    Viral carcinogenesis CASP8,HIST1H4I,HIST1H4H,PMAIP1,TRAF2,KAT2B,CDC42,BAX,CCND2,GTF2E1
    Epstein-Barr virus infection POLR2G,ENTPD1,FCER2,PSMD6,HSPA1L,POLR2C,HSPA2,PSMC4,NCOR2,HLA-DPB1
    Toll-like receptor signaling pathway CCL4,CCL3L3,IFNA8,AKT2,MAP2K2A,TLR7,CXCL8B.3,TAB2,CCL5,FADD
    Hepatitis C MAPK12,IFNAR2,PIK3R5,MAPK11,NFKB1,IFNA17,IFNA10,OCLN,MAPK10,CLDN4
    Herpes simplex infection TAF9B,IFNAR1,PER1,LTA,MYD88,HLA-DOB,IFNGR2,IFNA5,MHC2DAB,JAK2A
    NF-kappa B signaling pathway PLCG1,IL-8,TNFRSF11A,BLNK,BCL2L1,TRADD,BTK,TNFSF13B,IRAK1,TNFSF11
    Small cell lung cancer BIRC3,CASP9,FHIT,FN1,MAX,LAMA4,TRP53,LAMB1,PTGS2,PTK2

    Protein Function

    TRAF3 has several biochemical functions, for example, ligase activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.

    Function Related Protein
    thioesterase binding CALM1,CALM2,CALM3,CALM,TRAF2,TRAF4,RAC1,ADRA2A,HAUS7,TRAF5
    protein kinase binding SPAG16,SYN1,BORA,PRKAG1,DCX,DUSP3,PRKACA,DPYSL2,SCN5A,CYLD
    protein phosphatase binding MVP,DLG3,RPA3,JAK1,STAT6,EGFR,LCK,FLT4,FGF19,GNB2L1
    signal transducer activity BMX,ADRB2B,PLCB1,CANT1,TMTOPS3B,GHRHR2,SH2B2,V1RA8,TRHRB,OLFR502
    protein binding CCDC87,DPEP3,TTC12,TRMT12,PRKDC,AGFG1,INTS5,RAB3A,CCL5,ZMAT2
    zinc ion binding KDM2A,USP44,NR5A2,CNOT4B,MICALL2,NR1D4B,ZMIZ1,MMP9,DPF2L,RXRBA
    ligase activity CBL,LTN1,RNF4,TRIM50,PPIL2,MID2,MYLIPB,UBR3,RNF217,SHPRH
    ubiquitin protein ligase binding HM13,ATP6V0C,PIAS2,LTBR,GPR37,FLJ11011L,TUBA1B,UBE2V2,GABARAP,UBE2V1
    tumor necrosis factor receptor binding TNFB,FADD,LTA,TNFSF13B,TRAF4,TRIM37,EDA,TRAF6,TRAF2,CASP8

    Interacting Protein

    TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.

    TANK;TRAF3IP1;RIPK2;CD40

    Resources

    References

    • Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).
    • Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).

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