TRAF3
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Official Full Name
TNF receptor-associated factor 3 -
Overview
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. -
Synonyms
TRAF3;TNF receptor-associated factor 3;LAP1;CAP-1;CRAF1;CD40bp;CD40 binding protein;CD40 associated protein 1;LMP1-associated protein 1;CD40 receptor associated factor 1;CAP 1;CD40-binding protein;LAP 1;MIPT3;TRAF3_HUMAN
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- GST
- DDK&Myc
- His
- Non
- Flag
Involved Pathway
TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway,Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | PPP1CB,IFNA5,IKBKE,SRSF9,TAF10,STAT2,HLA-DRB1,USP7,CDC34A,MHC2A |
| Hepatitis C | CLDN3,TRP53,STAT1,CLDN2,SOCS3,CLDN14,IKBKB,IFNA1,TBK1,IFNA8 |
| TNF signaling pathway | CASP8,MAP3K7,SELE,MAPK11,PIK3CD,CX3CL1,BCL3,CREB5,CCL2,ITCH |
| Viral carcinogenesis | HIST1H2BC,YWHAB,RBPJL,HLA-G,CREB3L3,HIST1H2BG,GTF2H4,HIST1H4B,RBL1,HIST1H4N |
| Pathways in cancer | CBLB,CASP8,GNG11,WNT8A,RAC2,HDAC1,ETS1,PRKCB,RAD51,VHL |
| Small cell lung cancer | ITGA3,AKT2,LAMB3,APAF1,NOS2,TRAF2,LAMC1,BIRC8,BIRC7,PIK3R1 |
| Epstein-Barr virus infection | POLR3G,PIK3R2,PTMA,TRAF5,RBPJ,HSPA1A,POLR3H,NFKB1,MAPK13,NFKBIE |
| NF-kappa B signaling pathway | TNFRSF1A,CCL4L1,BLNK,MAP3K7IP3,CXCL12,PLCG2,LTA,BCL2A1,GM1987,TRAF6 |
| Toll-like receptor signaling pathway | IFNA13,MAP2K7,TICAM2,MAPK9,FADD,CD40,MAP2K2A,RAC1,IFNA6,PIK3CA |
Protein Function
TRAF3 has several biochemical functions, for example, ligase activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | GATB,UBE2L3A,KCMF1,HACE1,MYLIPB,ZNRF1,SIAH2,RNF125,RNF40,RBX1 |
| ubiquitin-protein transferase activity | FBXO30A,WWP2,MUL1,TRAF6,UBE2C,FBXO7,TRIM62,UBE2D2A,TRAF4A,UBE2E3 |
| tumor necrosis factor receptor binding | TRAF4,ERAP1,TRIM37,FADD,EDA,TRADD,TNFSF12,TNFSF10L4,TNFSF10L3,TRAF2 |
| thioesterase binding | CALM,TRAF4,TRAF6,ADRA2A,ARF6,TRAF1,CALM3,TRAF2,TRAF5,CDC42 |
| zinc ion binding | TRIM69,RNF26,CNBP,RNF168,MARCH2,MMP13A,CDA,CA4B,APOBEC1,HRG |
| signal transducer activity | PLK2,TAAR14I,OLFR18,DRD2A,SHISA5,GNAO1B,STAT3,TICAM2,MTNR1AL,MRGPRA8 |
| ubiquitin protein ligase binding | CXCR4,CUL3B,SMAD7,PA2G4,YWHAE,SNCAIP,UBE2NB,CLU,PRDX6,CUL4A |
| protein binding | AP2A1,ADAP2,CHTOP,CEACAM21,TIMM8A,AP5Z1,CNGA1,EIF3H,TPRKB,KDM5A |
| protein kinase binding | PAK2,CDKN2D,DNM2,TTN,AXIN2,NPR1,CAMK2N2,CCNL2,CD8A,SMAD3 |
Interacting Protein
TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.
TANK;TRAF3IP1;RIPK2;CD40
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References
- Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).
- Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).
