TPP2
-
Official Full Name
tripeptidyl peptidase II -
Overview
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. -
Synonyms
TPP2;tripeptidyl peptidase II;tripeptidyl-peptidase 2;TPP-II;tripeptidyl-peptidase II;tripeptidyl aminopeptidase;TPP-2;FLJ40359
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- His
- Non
- Flag
- Myc
- Avi
- Fc
- DDK
Involved Pathway
TPP2 involved in several pathways and played different roles in them. We selected most pathways TPP2 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | ASB6,CYBA,ASB17,SH3RF1,TRAF7,ASB2,RNF25,ERAP2,UBR1,CMTM2A |
| Adaptive Immune System | AGO1,NA,CD200,CDKN1B,RNF144B,CTLA4,IGLC2,CD300LG,WWP1,RACGAP1 |
| Immune System | ARIH2,BTR22,ABI1,NLRP4E,FBXO17,KIF5A,CASP2,LILRA1,GBP5,Mill2 |
| Antigen processing: Ubiquitination & | FBXO3,TRIM9,UBA5,UBE2U,UFL1,FBXO44,UBE2J2,HUWE1,RNF25,UBE2L6 |
| Class I MHC mediated antigen processing & | ASB14,RNF4,LRR1,FBXO3,PJA1,SH3RF1,ATG7,MKRN1,ASB18,TRIM11 |
| Proteasome degradation | ATG7,VPRBP,DTX3L,RNF220,TRIM39,ASB4,KLHL20,MKRN1,UBE2E3,GAN |
Protein Function
TPP2 has several biochemical functions, for example, aminopeptidase activity,endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPP2 itself. We selected most functions TPP2 had, and list some proteins which have the same functions with TPP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | APH1B,PSMA5,PSMB10,PCSK6,ELANE,PSMB11,SENP3A,PSMB7,KLK1B16,CASP1 |
| aminopeptidase activity | NPEPPS,PHEX,METAP2A,PEPD,LAP3,DNPEP,LTA4H,METAP2,XPNPEP2,CTSH |
| serine-type endopeptidase activity | PRSS21,CTSH,TMPRSS7,PRSS50,FURINB,F10,CTSC,TMPRSS11G,PROC,PLAU |
| protein binding | UBE2B,SIPA1L2,ACBD3,ARHGAP5,LILRB3,FAM65B,RBFOX2,VDR,EIF4A2,Raet1c |
| tripeptidyl-peptidase activity | ACE,TPP1 |
Interacting Protein
TPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPP2.
POLB;EHHADH;PPP1R16A;MCC;HLA-B;GAMMAHV.ORF68
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