TPM2
-
Official Full Name
tropomyosin 2 (beta) -
Overview
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TPM2;tropomyosin 2 (beta);AMCD1, arthrogryposis multiplex congenital, distal, type 1;tropomyosin beta chain;DA1;tropomyosin-2;DA2B;NEM4;TMSB;AMCD1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- Rhesus macaque
- Canine
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TPM2 involved in several pathways and played different roles in them. We selected most pathways TPM2 participated on our site, such as Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dilated cardiomyopathy | DAG1,CACNA2D1,MYH7,TGFB2,TGFB3,ITGB7,DMD,PRKACA,Itga10&Itgb1,CACNG3 |
| Hypertrophic cardiomyopathy (HCM) | CACNG3,TNNI3,ITGB5,ITGA9,PRKAG3,ITGB6,TPM1,ITGB3,ACTG1,CACNB3 |
| Cardiac muscle contraction | TPM3,ATP1A1,COX5B2,TNNC1,ATP1B2B,COX8A,CACNG7A,TPMA,CACNB4,ATP1B3B |
| Adrenergic signaling in cardiomyocytes | ATP2B1A,CALM,PPP2R5CB,ATP1B3,PIK3CA,PPP1CAB,ACTC1,SCN5A,CALM2,TPMA |
Protein Function
TPM2 has several biochemical functions, for example, actin binding,structural constituent of muscle. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM2 itself. We selected most functions TPM2 had, and list some proteins which have the same functions with TPM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of muscle | ACTN2,MYL6B,DMD,TPM1,ACTN3,MYL1,ASPH,MYOM1,ANKRD2,TCAP |
| actin binding | DIAPH1,PLECA,SCINLA,PXK,DBNL,INPPL1A,GIPC1,ESPN,MYH1,CAPZA1A |
Interacting Protein
TPM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM2.
EPB41;MCC;Pafah1b1;Poc1b;Ccdc15;Zwint;ck024_mouse;SNAPIN;SKIL;MAST2;AKT1;MYH9;IQGAP1;CAPZA2;Tpm1;Actb;PPP1CB;GRB2
Resources
Related Services
Related Products
References
- Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
- Tang, HY; Beer, LA; et al. Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer. JOURNAL OF PROTEOMICS 89:165-178(2013).
- Zhang, JT; Wang, KJ; et al. Using Proteomic Approach to Identify Tumor-Associated Proteins as Biomarkers in Human Esophageal Squamous Cell Carcinoma. JOURNAL OF PROTEOME RESEARCH 10:2863-2872(2011).
