TOPORS
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Official Full Name
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -
Overview
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. -
Synonyms
TOPORS;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase;retinitis pigmentosa 31 (autosomal dominant) , RP31, topoisomerase I binding, arginine/serine rich;E3 ubiquitin-protein ligase Topors;LUN;TP53BPL;SUMO1-protein E3 lig
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TOPORS-3354H | Recombinant Human TOPORS, His-tagged | E.coli | Human | His | 1-332aa | |
| TOPORS-4903R | Recombinant Rhesus monkey TOPORS Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TOPORS-4717R | Recombinant Rhesus Macaque TOPORS Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| TOPORS-4717R-B | Recombinant Rhesus Macaque TOPORS Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
TOPORS involved in several pathways and played different roles in them. We selected most pathways TOPORS participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TOPORS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TOPORS has several biochemical functions, for example, DNA binding,DNA topoisomerase binding,SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOPORS itself. We selected most functions TOPORS had, and list some proteins which have the same functions with TOPORS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | FBXL7,RNF139,FANCL,RNF213,MARCH5L,BRCA1,PEX12,HECTD1,MARCH6,FBXO40.1 |
| SUMO transferase activity | NSMCE2,SUMO4,CBX4,UBE2IB,PIAS4,SUMO3,UBE2I,UBE2IA,SUMO1,PIAS3 |
| ligase activity | MARCH10,HECW1,RFWD2,UBE3B,TRIM2,MID1,UBE3A,TRAIP,UBR4,MARCH3 |
| DNA topoisomerase binding | SETMAR |
| antigen binding | IL7R,IGKC,IGHM,LILRA3,HNRNPM,LILRB4,FCN3,IGJ,IGLL1,PPP2R1A |
| protein binding | RGS19,PCGF2,LPHN1,BOLA1,CALM2,CTNNA2,DOK4,PARD6B,NAPB,SESN2 |
| zinc ion binding | UQCRC2A,TAF3,NANOS1,SF3A3,NR1D2,DTNB,CIZ1,PRDM2,SUV39H1,TRIM33 |
| ubiquitin protein ligase activity | MED23,RNF25,RNF222,RNF165,UBE2R2,UBE2S,CBL,RAG2,SIAH1A,UBE2H |
| DNA binding | FOXN1,ZNF490,ZNF350,NFIL3,HIST1H101,LHX8,ZNF488,YEATS4,NFIB,ZFP35 |
Interacting Protein
TOPORS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOPORS here. Most of them are supplied by our site. Hope this information will be useful for your research of TOPORS.
TP53;CASP8;Rep78;UBE2L6;Tp53;Rep68;UBE2D1;UBE2D3;UBE2N;UBE2D2;SATB1;SETX;SNIP1;pyrC;UBE2W;UBE2D4;UBE2J1
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