TOPORS

  • Official Full Name

    topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

  • Overview

    This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.

  • Synonyms

    TOPORS;topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase;retinitis pigmentosa 31 (autosomal dominant) , RP31, topoisomerase I binding, arginine/serine rich;E3 ubiquitin-protein ligase Topors;LUN;TP53BPL;SUMO1-protein E3 lig
Cat.# Product name Source (Host) Species Tag Protein Length Price
TOPORS-3354H Recombinant Human TOPORS, His-tagged E.coli Human His 1-332aa
TOPORS-4903R Recombinant Rhesus monkey TOPORS Protein, His-tagged Mammalian Cells Rhesus macaque His
TOPORS-4717R Recombinant Rhesus Macaque TOPORS Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
TOPORS-4717R-B Recombinant Rhesus Macaque TOPORS Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    TOPORS involved in several pathways and played different roles in them. We selected most pathways TOPORS participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TOPORS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    TOPORS has several biochemical functions, for example, DNA binding,DNA topoisomerase binding,SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOPORS itself. We selected most functions TOPORS had, and list some proteins which have the same functions with TOPORS. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding MHC1UKA,FCN3,TGFB1,LCK,Ighg,PPP2R1A,KIR2DL3,LAG3,IGKC,LILRA3
    ligase activity FANCL,RNF40,TRIML1,DTX2,RNF139,XIAP,ATG10,ZNRF1,CBLL1,TTLL2
    ubiquitin-protein transferase activity FBXO25,RNF125,TRIM69,UBE2Q2,RLIM,TRIM68,RNF182,UBE2B,CNOT4,FBXL14A
    DNA binding C3orf37,CARF,CSDE1,MKXA,Trl,NKX2-6,MEIS4.1A,ZNF224,TDEANC2,CHD8
    SUMO transferase activity SUMO4,SUMO3,UBE2I,PIAS3,SUMO1,MUL1,UBE2IA,CBX4,PIAS4,UBE2IB
    ubiquitin protein ligase activity UBE2V1,ASB4,CMTM2A,WWP1,MED10,UBE2U,TRIM59,UBE2T,UBE2V2,UBE2R2
    zinc ion binding RNF125,UNKL,CXXC1A,TRIM6,KAT7,CA7,GM3258,DRP2,PGLYRP2,PCGF5
    protein binding PXMP4,TGIF2LY,MAPRE3,LGR5,FAS,SRI,IMPA1,EIF4G1,CIRH1A,SPTBN1
    DNA topoisomerase binding SETMAR

    Interacting Protein

    TOPORS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOPORS here. Most of them are supplied by our site. Hope this information will be useful for your research of TOPORS.

    TP53;CASP8;Rep78;UBE2L6;Tp53;Rep68;UBE2D1;UBE2D3;UBE2N;UBE2D2;SATB1;SETX;SNIP1;pyrC;UBE2W;UBE2D4;UBE2J1

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