TOP3B

  • Official Full Name

    topoisomerase (DNA) III beta

  • Overview

    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.

  • Synonyms

    TOP3B;topoisomerase (DNA) III beta;DNA topoisomerase 3-beta-1;DNA topoisomerase 3 beta 1;DNA topoisomerase III beta 1;FLJ39376;TOP 3B;TOP3B1;Topo III beta;Topoisomerase DNA III beta;Topoisomerase III beta;OTTHUMP00000198579;OTTHUMP00000198581;DNA topoisomerase III beta-1

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • His&T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TOP3B-3353H Recombinant Human TOP3B, GST-tagged E.coli Human GST 510-702aa
TOP3B-1330C Recombinant Chicken TOP3B Mammalian Cells Chicken His
TOP3B-4901R Recombinant Rhesus monkey TOP3B Protein, His-tagged Mammalian Cells Rhesus macaque His
TOP3B-8247H Recombinant Human TOP3B protein, His & T7-tagged E.coli Human His&T7 Met1~Asp250
TOP3B-1810HCL Recombinant Human TOP3B cell lysate Human Non
TOP3B-4715R Recombinant Rhesus Macaque TOP3B Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
TOP3B-4715R-B Recombinant Rhesus Macaque TOP3B Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    TOP3B involved in several pathways and played different roles in them. We selected most pathways TOP3B participated on our site, such as Homologous recombination,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Homologous recombination MRE11A,FUZ,RAD51L1,RAD52,RAD54L,RPA4,BLM,TOP3A,RAD51C,CDK5R2
    Fanconi Anemia Pathway ATRIP,RAD51,C19orf40,POLN,RAD51C,RPA1,ERCC1,FANCM,HES1,POLI

    Protein Function

    TOP3B has several biochemical functions, for example, DNA binding,DNA topoisomerase activity,DNA topoisomerase type I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3B itself. We selected most functions TOP3B had, and list some proteins which have the same functions with TOP3B. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ARHGEF38,BET1,C1QL1,GPRASP1,UBE2D3,KCNG3,ACPL2,CD81,TRAF6,SNRNP25
    DNA topoisomerase type I activity CDK5R2,TOP1,TOP1L,TOP1MT,TOP3A
    DNA topoisomerase activity CDK5R2
    DNA binding HER8A,SPATA24,ZFP692,PIAS1,POU6F2,E2F2,TAF9,POU4F2,ORC6L,JARID2B
    poly(A) RNA binding RAVER1,DIMT1L,PEF1,NGDN,NIP7,EIF4H,MRPL45,RTCD1,IFIT2,ZFP622

    Interacting Protein

    TOP3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3B here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3B.

    ADAMTSL4;SPRED2;TRIM41;MID2;PNMA2;SSX2IP;AARSD1;KRTAP4-12

    Resources

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