TOP3A
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Official Full Name
topoisomerase (DNA) III alpha -
Overview
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. -
Synonyms
TOP3A;topoisomerase (DNA) III alpha;TOP3;DNA topoisomerase 3-alpha;DNA topoisomerase 3 alpha;DNA topoisomerase III alpha;TOP 3;TOP3A_HUMAN;topoisomerase (DNA) III;topoisomerase III alpha;topo III-alpha;OTTHUMP00000065693
Recombinant Proteins
- Human
- Mouse
- Chicken
- Arabidopsis thaliana
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- His
- His&T7
- Twin Strep
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TOP3A-3352H | Recombinant Human TOP3A, His-tagged | E.coli | Human | His | 652-1001aa | |
| TOP3A-17232M | Recombinant Mouse TOP3A Protein | Mammalian Cells | Mouse | His |
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| TOP3A-2343C | Recombinant Chicken TOP3A | Mammalian Cells | Chicken | His |
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| TOP3A-4584C | Recombinant Chicken TOP3A | Mammalian Cells | Chicken | His |
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| TOP3A-4585C | Recombinant Chicken TOP3A | Mammalian Cells | Chicken | His |
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| TOP3A-4586C | Recombinant Chicken TOP3A | Mammalian Cells | Chicken | His |
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| TOP3A-8248H | Recombinant Human TOP3A protein, His & T7-tagged | E.coli | Human | His&T7 | Lys35~Ser179 |
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| TOP3A-1096A | Recombinant Arabidopsis thaliana (Mouse-ear cress) TOP3A Protein (Glu631-Phe926), N-TwinStrep tagged | Insect Cells | Arabidopsis thaliana | Twin Strep | Glu631-Phe926 |
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| TOP3A-2853H | Recombinant Human TOP3A protein(911-990 aa), C-His-tagged | E.coli | Human | His | 911-990 aa |
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| TOP3A-6490H | Recombinant Human TOP3A Protein (Lys35-Ser179), N-His tagged | E.coli | Human | His | Lys35-Ser179 |
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| TOP3A-9521M | Recombinant Mouse TOP3A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TOP3A-9521M-B | Recombinant Mouse TOP3A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TOP3A involved in several pathways and played different roles in them. We selected most pathways TOP3A participated on our site, such as Homologous recombination,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | RPA3,SYCP3,SSBP1,NBN,RAD51B,BRCA2,RAD52,RPA4,MRE11A,POLD2 |
| Fanconi Anemia Pathway | MUS81,FANCI,FANCE,POLH,APITD1,RAD51,BLM,FUZ,CDK5R2,USP36 |
Protein Function
TOP3A has several biochemical functions, for example, DNA binding,DNA topoisomerase type I activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3A itself. We selected most functions TOP3A had, and list some proteins which have the same functions with TOP3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF473,GATA3,BLM,TRP53,SMARCB1A,SOX1B,HIST1H3H,NR1D2A,LUC7L3,HIST1H4B |
| DNA topoisomerase type I activity | TOP1L,TOP3B,TOP1MT,TOP1,CDK5R2 |
| zinc ion binding | FUS,MICALL2,TRIM21,ADAM20,ASH1L,MORC4,ZNF212,TRIM43B,BSPRY,RABGEF1L |
| protein binding | HSFX1,MAPK6,CHPF,HSPB2,TBC1D9B,NRIP2,MAPK3,FBP1,GIT2,TRIM44 |
Interacting Protein
TOP3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3A here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3A.
BLM;RMI1;TERF2;RIF1;FANCA;ssdna_da;TP53
Resources
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References
- Kim, HS; Cross, GAM; et al. Identification of Trypanosoma brucei RMI1/BLAP75 Homologue and Its Roles in Antigenic Variation. PLOS ONE 6:-(2011).
- Chiappori, AA; Zheng, Z; et al. Features of Potentially Predictive Biomarkers of Chemotherapeutic Efficacy in Small Cell Lung Cancer. JOURNAL OF THORACIC ONCOLOGY 5:484-490(2010).
