TNXB
-
Official Full Name
tenascin XB -
Overview
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5 and 3 ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TNXB;tenascin XB;TNXB1, TNXB2;tenascin-X;TNXBS;XB;XBS;Ehlers Danlos like syndrome;Hexabrachion like protein;HXBL;NXB2;Tenascin X precursor;Tenascin XB1;Tenascin XB2;TENX;TN X;TNX;TNXB1;TNXB2;hexabrachion-like protein;growth-inhibiting protein 45;TN-X
Recombinant Proteins
- Human
- Mouse
- E.coli
- CHO
- HEK293
- GST
- His
- His&T7
- Non
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TNXB-3341H | Recombinant Human TNXB, GST-tagged | E.coli | Human | GST | C-term-353aa | |
| TNXB-323H |
Active Recombinant Human TNXB, His-tagged
|
CHO | Human | His | 1-673 a.a. |
|
| Tnxb-1989M | Recombinant Mouse Tnxb protein, His & T7-tagged | E.coli | Mouse | His&T7 | Thr3824~Asn4071 |
|
| TNXB-607H | Recombinant Human TNXB Protein, His-tagged | E.coli | Human | His |
|
|
| TNXB-876HCL | Recombinant Human TNXB 293 Cell Lysate | HEK293 | Human | Non |
|
|
| TNXB-4546H | Recombinant Human TNXB protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 1-673aa |
|
| TNXB-6488H | Recombinant Human TNXB Protein (Glu3835-Asp4088), N-GST tagged | E.coli | Human | GST | Glu3835-Asp4088 |
|
Involved Pathway
TNXB involved in several pathways and played different roles in them. We selected most pathways TNXB participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNXB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | TIMP3,TNR,GLS,ZFPM2,BCL2L2,CCNE1,MMP16,WNT3A,CDC25B,BMI1 |
| PIK-Akt signaling pathway | MTCP1,LPAR4,IFNA13,GNGT1,MAP2K2,IL3RA,GRB2,IL4R,Ifna11,FGF16 |
| Focal adhesion | RHOA,VEGFC,COL1A1,COL4A6,ITGA3B,PAK4,ITGB3,MAPK6,HRAS,COL1A1A |
| ECM-receptor interaction | ITGA2,CD44,COL6A4,ITGA3B,COL6A6,COL2A1,ITGAV,FN1A,GP6,GP9 |
Protein Function
TNXB has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by TNXB itself. We selected most functions TNXB had, and list some proteins which have the same functions with TNXB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | FRAT2,COL5A2,TMEM151B,NAT14,MORC1,PSTPIP1B,FAM46AB,ANKRD12,TTLL2,DCDC2A |
Interacting Protein
TNXB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNXB here. Most of them are supplied by our site. Hope this information will be useful for your research of TNXB.
BANP;PCOLCE;TFAP2A;q7ard1_yerpe;purA;TFAP2C;E2F3
Resources
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References
- Chen, XY; Li, R; et al. Identification of differentially expressed genes in hypothalamus of chicken during cold stress. MOLECULAR BIOLOGY REPORTS 41:2243-2248(2014).
- Endo, T; Ariga, H; et al. Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5. MOLECULAR AND CELLULAR BIOCHEMISTRY 320:53-66(2009).
- Levy, P; Ripoche, H; et al. Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1. CLINICAL CANCER RESEARCH 13:398-407(2007).
