TNPO1

  • Official Full Name

    transportin 1

  • Overview

    This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

  • Synonyms

    TNPO1;transportin 1;MIP;TRN;IPO2;MIP1;KPNB2;transportin-1;importin 2;importin beta 2;importin beta-2;karyopherin beta-2;M9 region interaction protein;karyopherin (importin) beta 2

Recombinant Proteins

  • Mouse
  • Human
  • Cattle
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TNPO1-17203M Recombinant Mouse TNPO1 Protein Mammalian Cells Mouse His
TNPO1-31605TH Recombinant Human TNPO1 Wheat Germ Human Non 117 amino acids
TNPO1-341C Recombinant Cattle TNPO1 Protein, His-tagged E.coli Cattle His Pro593~Val836
TNPO1-342H Recombinant Human TNPO1 Protein, His-tagged E.coli Human His Lys626~Val836
Tnpo1-343M Recombinant Mouse Tnpo1 Protein, His-tagged E.coli Mouse His Cys597~Ile837
TNPO1-9503M Recombinant Mouse TNPO1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TNPO1-9503M-B Recombinant Mouse TNPO1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TNPO1 involved in several pathways and played different roles in them. We selected most pathways TNPO1 participated on our site, such as Assembly of the primary cilium,Gene Expression,Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Organelle biogenesis and maintenance BBS5,CNGA2,C10orf2,DYNLL2B,MRPS28,TMEM67,TTC8,CYS1,TTC30A1,CEP89
    Intraflagellar transport TTC30B,DYNLRB2,IFT20,IFT80,HSPB11,RABL5,FLR,KIFAP3A,IFT27,KIF3B
    Assembly of the primary cilium PKD1,CEP290,MKKS,ACTR1A,ODF2,DCTN2,DCTN1A,DYF-1,EXOC5,CSNK1D
    Regulation of mRNA stability by proteins that bind AU-rich elements ZFP36L1B,SET,HUG,KHSRP,SETB,SETA,ELAVL1,ZFP36L1A,HNRNPD,ZFP36L1
    Gene Expression NR2F1B,ZNF192,ZNF333,APEH,CLNS1A,CHD4A,ZNF200,AARS,ZNF490,CCNT2A

    Protein Function

    TNPO1 has several biochemical functions, for example, Ran GTPase binding,nuclear localization sequence binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNPO1 itself. We selected most functions TNPO1 had, and list some proteins which have the same functions with TNPO1. You can find most of the proteins on our site.

    Function Related Protein
    Ran GTPase binding NXT1,RANBP2,DPY19L2,IPO11,XPO5,RANBP1,RANBP10,TNPO2,IPO13,XPO1
    poly(A) RNA binding NOP16,DYNC1LI1,HLA-A,NAP1L4,ZFP207,C11orf68,GLTSCR2,HNRNPH1,MSI2,EIF3D
    protein transporter activity AP2S1,SOSTDC1B,CALCR,KPNA1,C11orf73,RAMP1,XPO1,XPO5,RAMP2,TNPO3
    protein binding FAM49B,DDAH2,ERP29,EIF3B,IMPA1,DDIT4L,GIMAP5,NOP10,DNER,Icosl
    nuclear localization sequence binding KPNA3,NFKBIA,TNPO2,IPO4,BRAP,KPNB1,IPO5,KPNA5,NUP214,KPNA2

    Interacting Protein

    TNPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNPO1.

    RAN;NXF1;LRRK2;L1;L2;E6;L1;L1;ACTB;GRB2;YWHAZ;glsA2;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;midostaurin

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