TNNT1
-
Official Full Name
troponin T type 1 (skeletal, slow) -
Overview
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
troponin T, slow skeletal muscle;sTnT;tnTs;troponin T1, skeletal, slow;slow skeletal muscle troponin T
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Bovine
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- His
- Flag
- Non
- His&Fc&Avi
- N-His&C-Myc
- Myc&DDK
Involved Pathway
TNNT1 involved in several pathways and played different roles in them. We selected most pathways TNNT1 participated on our site, such as Muscle contraction,Striated Muscle Contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Muscle contraction | TMOD1,DESMA,MYBPC2A,SMYHC2,TNNT3,TNNI1,DES,TNNI2,DESMB,MYBPC3 |
| Striated Muscle Contraction | SMYHC3,DESMB,SMYHC2,VIML,TNNT3B,TMOD3,ACTA1B,MYBPC1,TMOD4,TNNI2A.4 |
Protein Function
TNNT1 has several biochemical functions, for example, protein binding,tropomyosin binding,troponin T binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNT1 itself. We selected most functions TNNT1 had, and list some proteins which have the same functions with TNNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IWS1,MAPK10,MDFIC,PTBP1,HINFP,SPRYD7,CDK1,HHLA2,SLAMF1,KLRC1 |
| troponin T binding | TNNC1,TNNI2,TNNI3 |
| tropomyosin binding | NEBL,TNNT3,TMOD1,LMOD2A,LMOD1,S100A6,TMOD4,TMOD3,LMOD3,TMOD2 |
Interacting Protein
TNNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNT1.
TPM1;LDOC1;TBPL1;NFE2L2;TPM3;KRT40;CCDC136
Resources
Related Services
Related Products
References
