TNK2

  • Official Full Name

    tyrosine kinase, non-receptor, 2

  • Overview

    Ack1 and Ack2 (activated cdc42-associated kinase 1 and 2) are non-receptor tyrosine kinases that consist of a tyrosine kinase core, an SH3 domain, a cdc42/Rac-binding (CRIB) domain, a Ralt homology region and a proline-rich region (1,2). Ack1 and 2 are th

  • Synonyms

    TNK2;tyrosine kinase, non-receptor, 2;activated CDC42 kinase 1;ACK;ACK1;activated Cdc42 associated kinase 1;p21cdc42Hs;activated p21cdc42Hs kinase;activated Cdc42-associated kinase 1;tyrosine kinase non-receptor protein 2;ACK-1;FLJ44758;FLJ455

Recombinant Proteins

  • Mouse
  • Human
  • Rat
  • Mammalian Cells
  • E.Coli/Yeast
  • Insect Cells
  • E.coli
  • HEK293
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TNK2-17186M Recombinant Mouse TNK2 Protein Mammalian Cells Mouse His
TNK2-26295TH Recombinant Human TNK2 Human Non 110-476 a.a.
TNK2-26475TH Recombinant Human TNK2 Human Non 110-476 a.a.
Tnk2-3109M Recombinant Mouse Tnk2, His-tagged E.Coli/Yeast Mouse His 1055
TNK2-6205R Recombinant Rat TNK2 Protein Mammalian Cells Rat His
TNK2-715HCL Recombinant Human TNK2 cell lysate Insect Cells Human Non
TNK2-0755H Recombinant Human TNK2 Protein (G110-W476), Tag Free Insect Cells Human Non G110-W476
TNK2-0756H Recombinant Human TNK2 Protein (G110-W476), GST tagged Insect Cells Human GST G110-W476
TNK2-458H Recombinant Human TNK2 Protein, His-tagged E.coli Human His Leu126-Leu385
TNK2-5862R Recombinant Rat TNK2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
TNK2-5862R-B Recombinant Rat TNK2 Protein Pre-coupled Magnetic Beads HEK293 Rat
TNK2-9489M Recombinant Mouse TNK2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TNK2-9489M-B Recombinant Mouse TNK2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TNK2 involved in several pathways and played different roles in them. We selected most pathways TNK2 participated on our site, such as CDC42 signaling events,EGFR1 Signaling Pathway,Focal Adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EGFR1 Signaling Pathway ZPR1,APPL2,WNK1,GRB7,TNIP1,GRB10,ZNF259,PITPNA,KLF11,CEBPB
    Focal adhesion RHOB,HRASA,COL1A1,ILK,PRKCG,RAP1B,FLNC,MAPK1,AKT2L,ITGB1
    G13 Signaling Pathway RHPN2,CFL2,MYBPH,ARHGEF1A,RTKN,DIAPH1,MYL1,GNA13,CIT,SH3RF1
    CDC42 signaling events ARPC2,ARPC4,ACTR2,CFL1,ARPC1B,EPS8,IQGAP3,CDC42BPA,CTNNA1,BAIAP2

    Protein Function

    TNK2 has several biochemical functions, for example, ATP binding,GTPase inhibitor activity,WW domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNK2 itself. We selected most functions TNK2 had, and list some proteins which have the same functions with TNK2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ZNF225,ITGA1,CYGB1,CYP2C39,ITGB1,ATP2B3B,KDM5D,NRP1B,APLF,COL5A2
    GTPase inhibitor activity IPO5,CDC42SE1,GPS2,SLIT2,CPEB2,GPS1,RTKN,UBE4A,RHOH,PDE6D
    WW domain binding SCNN1G,KIF20B,WBP5,TMEM128,WBP11,TRAF4,WBP1,DNM2,TRP63,SHISA5
    identical protein binding MRFAP1L1,NDE1,HOOK3,DYNLT1,TPRG1L,SF1,CBLL1,PLDN,SNCA,DNM1
    protein serine/threonine/tyrosine kinase activity DYRK2,CLK1,DYRK1AA,RPS6KA2,AURKC,SGK1,DYRK1B,DYRK3,TESK2,PRKCG
    hormone receptor binding JAK2A,SRC,JAK3,TNK1,JAK2B,TNK2B
    ATP binding CSNK2A2A,AK7,ACSBG2,PIM1,MTHFD1B,ACTR2A,STK24B,NEK8,SNRKA,MCM3L
    protein serine/threonine kinase activity NEK7,PKN1,CDK14,GM4922,ACVR2A,ARAF,SIK2,PDK3,MARK1,PBK
    non-membrane spanning protein tyrosine kinase activity HCK,FRK,FGR,TXK,ZAP70,PRKCD,YRK,JAK3,TNK1,ITK

    Interacting Protein

    TNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNK2.

    CLTC;GRB2;NCK1;CDC42;SH2D1A;GALT

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