TNIK
-
Official Full Name
TRAF2 and NCK interacting kinase -
Overview
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK;domain that serves a regulatory function (Fu et al., 1999 (PubMed 10521462)). -
Synonyms
TNIK;TRAF2 and NCK interacting kinase;TRAF2 and NCK-interacting protein kinase;KIAA0551
Recombinant Proteins
- Human
- Rhesus macaque
- Sf9 Cells
- Wheat Germ
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- Non
- His
- Flag
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TNIK-1499H |
Active Recombinant Human TNIK, GST-tagged
|
Sf9 Cells | Human | GST | 1-367 aa |
|
| TNIK-20H | Recombinant Human TNIK protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 538 a.a. |
|
| TNIK-31580TH | Recombinant Human TNIK | Sf9 Cells | Human | Non | 367 amino acids |
|
| TNIK-4877R | Recombinant Rhesus monkey TNIK Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
|
|
| TNIK-85H | Recombinant Human TNIK protein, Flag-tagged, Biotinylated | Insect Cells | Human | Flag | 1-314 a.a. |
|
| TNIK-1801HCL | Recombinant Human TNIK cell lysate | Human | Non |
|
||
| TNIK-1072H | Recombinant Human TNIK Protein (D11-G314), His tagged | Insect Cells | Human | His | D11-G314 |
|
| TNIK-1073H | Recombinant Human TNIK Protein (D11-G314), Tag Free | Insect Cells | Human | Non | D11-G314 |
|
| TNIK-4691R | Recombinant Rhesus Macaque TNIK Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
|
|
| TNIK-4691R-B | Recombinant Rhesus Macaque TNIK Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
Involved Pathway
TNIK involved in several pathways and played different roles in them. We selected most pathways TNIK participated on our site, such as Cellular Senescence,Cellular responses to stress,Oxidative Stress Induced Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNIK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF receptor signaling pathway | MAP4K5,RFFL,NRK |
| Oxidative Stress Induced Senescence | RNF2,SUZ12A,RING1,SCMH1,CBX6A,KDM6B,PHC1,CBX8A,CBX8B,BMI1B |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | CYR61,MYOG,CDX1,AES,TLE4,TCF4,KCNIP4,KRT1,TLE2,HBP1 |
| Cellular responses to stress | EGLN3,PHC2,UBN1,RB1CC1,HMGA1,CDKN2C,ACD,HBXIP,RING1,CBX8B |
| Cellular Senescence | CEBPB,HIST4H4,UBN1,ASF1A,HIRA,RBBP4,KAT5,CBX8A,CDKN2D,CDK4 |
Protein Function
TNIK has several biochemical functions, for example, ATP binding,NOT MAP kinase kinase kinase kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNIK itself. We selected most functions TNIK had, and list some proteins which have the same functions with TNIK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT MAP kinase kinase kinase kinase activity | NRK,MINK1,TNIKB,MAP4K4,TNIKA |
| protein kinase activity | BMPR1BA,PLK1,Aatk,CSNK1G2B,KITB,CDK11A,NRBP2,IGF1RB,MAP4K5,MAP3K2 |
| ATP binding | PAN3,DDX43,MAPK14B,CCT4,NME2B.1,MB21D1,MAP2K4A,SYN1,ATP11C,MINK1 |
| protein serine/threonine kinase activity | WNK2,PRKCA,MELK,MOS,TGFBR1A,STK35L,STK38L,MAP3K8,RIOK1,PHKG1A |
| protein binding | STBD1,AJUBA,NRBF2,ATG14,C21orf7,CDK17,EXOSC8,VPS36,SERPINB8,CALCOCO1 |
Interacting Protein
TNIK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNIK here. Most of them are supplied by our site. Hope this information will be useful for your research of TNIK.
CTNNB1;TCF7L2;Dlg4;51460873;PDCD5;EIF3H;SEPT4;PPIH;BUB3;GLRX3;GOT2;SOD2;RPN2;ANXA2
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