TMEM127
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Official Full Name
transmembrane protein 127 -
Overview
This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. -
Synonyms
TMEM127;transmembrane protein 127;FLJ20507;FLJ22257
Recombinant Proteins
- Mouse
- Zebrafish
- Rhesus macaque
- Mus musculus
- Human
- zebrafish
- Mammalian Cells
- E.coli
- HEK293
- His
- His&Fc&Avi
Involved Pathway
TMEM127 involved in several pathways and played different roles in them. We selected most pathways TMEM127 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM127 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TMEM127 has several biochemical functions, for example, Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM127 itself. We selected most functions TMEM127 had, and list some proteins which have the same functions with TMEM127. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | RAB11FIP4,SYTL1,RAB3GAP1,BICD1,SYTL4,EXPH5,ULK1,CCDC64,TBC1D30,SGSM2 |
Interacting Protein
TMEM127 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMEM127 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMEM127.
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References
- Clauzure, M; Valdivieso, AG; et al. Disruption of Interleukin-1 beta Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function. PLOS ONE 9:-(2014).
- Delarasse, C; Smith, P; et al. Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice. IMMUNOLOGY 140:456-464(2013).
