TM4SF1
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Official Full Name
transmembrane 4 L six family member 1 -
Overview
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008] -
Synonyms
TM4SF1;transmembrane 4 L six family member 1;L6;H-L6;M3S1;TAAL6;transmembrane 4 L6 family member 1;tumor-associated antigen L6;transmembrane 4 superfamily member 1;membrane component chromosome 3 surface marker 1;membrane component, chromosome 3, surface marker 1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Mus musculus
- Pongo Abelii
- E.coli
- HEK293
- Mammalian Cells
- Yeast
- GST
- Non
- His
- Avi
- Fc
Involved Pathway
TM4SF1 involved in several pathways and played different roles in them. We selected most pathways TM4SF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TM4SF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TM4SF1 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by TM4SF1 itself. We selected most functions TM4SF1 had, and list some proteins which have the same functions with TM4SF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | DEFB33,ZNF114,RAD21L1,HIST1H2BD,HHLA1,GHITM,FAM189A1,MIEF2,CCDC106A,IGSF21A |
Interacting Protein
TM4SF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TM4SF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TM4SF1.
HSPA8;DNAJA1;TUBA4A;DDR1;malS
Resources
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References
- Choi, SI; Kim, SY; et al. TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. ONCOTARGET 5:9823-9837(2014).
- Lin, CI; Merley, A; et al. TM4SF1: a new vascular therapeutic target in cancer. ANGIOGENESIS 17:897-907(2014).
