Tlr6
-
Official Full Name
toll-like receptor 6 -
Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. -
Synonyms
TLR6;toll-like receptor 6;CD286;OTTHUMP00000218187;CD286 antigen;TLR 6;Toll like receptor 6 precursor;OTTHUMP00000218188;OTTHUMP00000158730
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- CHO
- Sf21 Cells
- HEK293
- Human Cells
- Mammalian Cells
- His
- Fc
- Non
- hIgG4
- T7
- Avi
Involved Pathway
Tlr6 involved in several pathways and played different roles in them. We selected most pathways Tlr6 participated on our site, such as Activated TLR4 signalling,Chagas disease (American trypanosomiasis),Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases associated with the TLR signaling cascade | TIRAP,TICAM1,TLR10 |
| Chagas disease (American trypanosomiasis) | IL1B2,PPP2R2D,C1QB,Ccl12,IRAK1,PIK3R1,MAPK11,GNAI2,IFNB1,IFNGR2 |
| Diseases of Immune System | TIRAP,TLR10 |
| IRAK4 deficiency (TLR2/4) | TIRAP |
| Activated TLR4 signalling | JUN,S100A12,DUSP6,PELI3,AGER,SAA1,DHX9,S100B,TIRAP,TNIP2 |
| Immune System | CASP4,S100A12,KIR3DS1,TRIM11,TRIM62,CD300LF,CLEC6A,RNF138,BTR02,SIGLEC6 |
| Disease | RBP4,MYO18A,CHMP4B,DERL2,PPIAL4A,CCR5,FDX1,JAG1,BANF1,DPF1 |
| Innate Immune System | BTR29,FCN2,CHST13,C1rb,POLR3GLA,RNF216,DEFA1,CFHL3,SIGLEC14,BTR12 |
Protein Function
Tlr6 has several biochemical functions, for example, Toll-like receptor 2 binding,diacyl lipopeptide binding,lipopeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr6 itself. We selected most functions Tlr6 had, and list some proteins which have the same functions with Tlr6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipopeptide binding | CD1D2,CD1E,CD1d1,CD1B,CD1A,CD1D,CD1C |
| protein binding | GRIN2B,PSMD14,NCAM1A,TYR,PLEKHG6,AVPR2,COPS8,BANF1,THSD4,FGFR1B |
| protein heterodimerization activity | GABPB1,UNC13A,BMP2,UGT1A7,TENM3,HIST2H2AC,IKZF3,AHR,SIM1,CXorf15 |
| transmembrane signaling receptor activity | LILRA1,CD3G,PTH1RB,FZD8A,MRC1,GPR113,GPR133,THBD,OR4F29,NCR2 |
| receptor activity | PLXNA1,IGF2R,PAQR5A,ROBO4,NLGN3A,ADIPOR1,ATP6AP2,NLGN3B,CXCR3,EIF2D |
| diacyl lipopeptide binding | TLR2 |
| Toll-like receptor 2 binding | TLR1,TIRAP |
Interacting Protein
Tlr6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr6.
Resources
Research Area
NeuroinflammationImmune Regulatory Molecules on Endothelial Cells
NOD-like Receptors and the Inflammasome
Toll-Like Receptors (TLRs)
Related Services
Related Products
References
- Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
- Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).
