TLR10
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Official Full Name
toll-like receptor 10 -
Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. -
Synonyms
TLR10;toll-like receptor 10;CD290;MGC104967;MGC126398;MGC126399;OTTHUMP00000158729;CD290 antigen;TLR10_HUMAN;Toll like receptor 10;OTTHUMP00000218160;OTTHUMP00000218161;OTTHUMP00000218162
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST&His
- His&T7
- His
- Non
- His&Myc&SUMO
- Avi&Fc&His
Involved Pathway
TLR10 involved in several pathways and played different roles in them. We selected most pathways TLR10 participated on our site, such as Disease,Diseases associated with the TLR signaling cascade,Diseases of Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | CD200R1,GBP1,CLEC2H,LILRB3,SIGLEC7,CRTAM,HCST,SIGLEC6,UNC93B1,CYLD |
| Disease | KPNA5,JAG1,PSIP1,TCEB3,MTRR,FDX1,DERL2,RDBP,WHSC2,RBP1 |
| Diseases of Immune System | TLR6,TIRAP |
| Innate Immune System | DEFA1,DDOST,TRIM56,NLRP3,NLRP4B,BTR09,RNF135,TXNIPB,IFI16,PANX1A |
| Diseases associated with the TLR signaling cascade | TICAM1,TLR6,TIRAP |
| MyD88 cascade initiated on plasma membrane | ALCAMB,PELI2,DHX9,DUSP3B,AGER,TNIP2,CHST13,S100A12,PELI1,PELI3 |
Protein Function
TLR10 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR10 itself. We selected most functions TLR10 had, and list some proteins which have the same functions with TLR10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | OR4C13,SELE,OR115-6,KIR2DS2,GP6,NRXN3,TLR3,M6PR,LAG3,FZD9B |
Interacting Protein
TLR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR10.
Resources
Research Area
NeuroinflammationImmune Regulatory Molecules on Endothelial Cells
T Cell Antigen Recognition
NOD-like Receptors and the Inflammasome
Toll-Like Receptors (TLRs)
Related Services
Related Products
References
- Matas-Cobos, AM; Redondo-Cerezo, E; et al. The Role of Toll-Like Receptor Polymorphisms in Acute Pancreatitis Occurrence and Severity. PANCREAS 44:429-433(2015).
- Skipor, J; Szczepkowska, A; et al. PROFILE OF TOLL-LIKE RECEPTOR mRNA EXPRESSION IN THE CHOROID PLEXUS IN ADULT EWES. ACTA VETERINARIA HUNGARICA 63:69-78(2015).
