TLL1

  • Official Full Name

    tolloid-like 1

  • Overview

    This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    TLL1;tolloid-like 1;tolloid-like protein 1;ASD6;TLL;TLL1_HUMAN

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Myc&DDK
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TLL1-3254H Recombinant Human TLL1, His-tagged E.coli Human His 25-350aa
TLL1-6268C Recombinant Chicken TLL1 Mammalian Cells Chicken His
TLL1-8641Z Recombinant Zebrafish TLL1 Mammalian Cells Zebrafish His
TLL1-1786HCL Recombinant Human TLL1 cell lysate Human Non
TLL1-1110H Recombinant Human TLL1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
TLL1-1333HFL Recombinant Full Length Human TLL1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
TLL1-2203H Recombinant Human TLL1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
TLL1-2203H-B Recombinant Human TLL1 Protein Pre-coupled Magnetic Beads HEK293 Human
TLL1-419H Recombinant Human TLL1 Protein, His-tagged E.coli Human His Asp730-Ile1003
Tll1-6451M Recombinant Mouse Tll1 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
Tll1-743M Recombinant Mouse Tll1 protein, His-tagged E.coli Mouse His 148-347a.a.

    Involved Pathway

    TLL1 involved in several pathways and played different roles in them. We selected most pathways TLL1 participated on our site, such as Anchoring fibril formation,Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures COL4A6,COL6A1,LOX,COL5A1,PCOLCE,ABHD1,COL4A4,COL5A2,BMP1B,CTSL2
    Degradation of the extracellular matrix CMA1,TIMP2A,MGC174152,CTRB1,ADAM15,MMP15,TIMP2B,COL17A1,CAPNS1,MMP8
    Anchoring fibril formation BMP1A,TLL2,BMP1,BMP1B
    Collagen biosynthesis and modifying enzymes BMP1,LEPRE1,LEPREL1,EMID2,COL5A1,COL9A1B,COL8A2,COL4A6,COL6A2,SERPINH1A
    Extracellular matrix organization ADAMTS4,MMP8,MUSK,ITGB3A,MMP24,PCOLCEA,ADAM9,CTSLL,MMP13,TIMP2B
    Crosslinking of collagen fibrils LOXL4,LOXL2,LOXL1,BMP1B,LOXL3,ABHD1,BMP1,TLL2,PCOLCE,LOX
    Collagen formation COL25A1,COL8A2,SERPINH1B,COL16A1,PRP,COL13A1,ADAMTS3,COL28A1,LOX,COL5A2

    Protein Function

    TLL1 has several biochemical functions, for example, calcium ion binding,collagen binding,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLL1 itself. We selected most functions TLL1 had, and list some proteins which have the same functions with TLL1. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding CBLB,NEIL1,RNF150,ADAM12,SPRYD5,ADAM15,MMP14,ZDHHC3B,DBF4,ESR2A
    collagen binding TGFBI,CHADL,SERPINH1B,SMAD7,DDR2,MTAP1A,ITGA10,VWF,SERPINH1A,GP6
    calcium ion binding TNNC1B,FKBP10B,CALML3,PCDH17,PCDH1A6,CRACR2B,DOC2B,STIM1,CALU,PDCD6
    metalloendopeptidase activity ECEL1,ADAM12,MMP30,THSD4,MMP1A,MMP14,ADAMTS8,UQCRC2A,BMP1A,MMP14B

    Interacting Protein

    TLL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLL1.

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