TLE2
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Official Full Name
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) -
Overview
Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene. -
Synonyms
TLE2;transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila);transducin like enhancer of split 2, homolog of Drosophila E(sp1);transducin-like enhancer protein 2;enhancer of split groucho 2;ESG;ESG2;FLJ41188;GRG2;Enhancer of split groucho-like protein 2;Groucho2;KIAA4188;MGC124808;mKIAA4188;Tle2 protein;TLE2_HUMAN;transducin like enhancer of split 2;Transducin like enhancer protein 2;Transducin-like enhancer of split 2, homolog of Drosophila E(spl);transducin-like enhancer of split 2, homolog of Drosophila E(sp1)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TLE2-7087Z | Recombinant Zebrafish TLE2 | Mammalian Cells | Zebrafish | His |
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| TLE2-1050HCL | Recombinant Human TLE2 293 Cell Lysate | HEK293 | Human | Non |
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| TLE2-1209H | Recombinant Human TLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Tle2-6448M | Recombinant Mouse Tle2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
TLE2 involved in several pathways and played different roles in them. We selected most pathways TLE2 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex,Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the beta-catenin:TCF transactivating complex | TLE1,TLE3,H3F3D,TLE4,PYGO1,SMARCA4,BCL9,ASH2L,LEO1,BCL9L |
| Repression of WNT target genes | TLE4,TLE3B,AES,TLE3 |
| Signaling by NOTCH | DTX2,RAB6A,MDK,MDKB,HEYL,DNER,TLE4,DLK1,MDKA,TLE3 |
| Deactivation of the beta-catenin transactivating complex | TLE3B,TLE4,TLE3,C,BCL9L,SOX13,SOX9A,BCL9,SOX32,SOX9B |
| Degradation of beta-catenin by the destruction complex | TLE4,FAM123B,TLE1,TLE3B,CTBP1,CTBP2,AES,TLE3 |
| NOTCH1 Intracellular Domain Regulates Transcription | HEYL,HEY1,TLE3,TLE4,HEY2,TLE1,TUBB3 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | IGF2BP1,SALL4,CDX4,CYR61,KRT1,TLE4,MYOG,AES,TNIK,ZCCHC12 |
| Signal Transduction | OXTRL,RTKN,DTX2,GPRC6A,EMR1,LGR6,TAC1,FGD4,WIF1,TAC2 |
Protein Function
TLE2 has several biochemical functions, for example, protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE2 itself. We selected most functions TLE2 had, and list some proteins which have the same functions with TLE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | SETD8,PSMC3,ZEB1,SIRT1,MECP2,SMARCA4,SUFU,EID1,SKOR2,POU1F1 |
| protein binding | LDHD,GYPC,ADCY6,LYSMD1,CCDC148,DPP3,FKBP8,FNDC3B,ZNF599,TAF2 |
Interacting Protein
TLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE2.
DDB1;NUDC;CUL4B
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