TKTL1
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Official Full Name
transketolase-like 1 -
Overview
The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TKTL1;transketolase-like 1;transketolase-like protein 1;TKR;TKT2;TK 2;TK2;TKT 2;TKTL1_HUMAN;Transketolase 2;Transketolase like 1;Transketolase like protein 1;Transketolase related protein;Transketolase-related protein;Transketolase2;transketolase-2;OTTHUMP00000024307;OTTHUMP00000024308
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TKTL1 involved in several pathways and played different roles in them. We selected most pathways TKTL1 participated on our site, such as Pentose phosphate pathway,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TKTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose phosphate pathway | FBP1B,TKTL2,GPI,PRPS1L1,PFKL,TKT,GPI1,ALDOAA,ALDOB,DERA |
| Carbon metabolism | GPIB,ADH5,PGAM2,PRPS1B,TPI1A,CPS1,PCCB,PGAM1B,HADHA,PGAM1A |
| Metabolic pathways | GART,UGT1A6B,SAT1A.1,PHOSPHO1,ATP6V0CA,SLC33A1,GUSB,POLG,ALG10,NME3 |
| Biosynthesis of amino acids | GLULC,CTH,PGAM2,ENO2,MTR,ALDH18A1,PYCR2,ENO1B,ASL,IDH3B |
Protein Function
TKTL1 has several biochemical functions, for example, metal ion binding,transketolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TKTL1 itself. We selected most functions TKTL1 had, and list some proteins which have the same functions with TKTL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ARL1,ZNF740,ZMYND12,ADIPOR2,ZBTB8A,NUFIP1,ZNF383,AMY1A,UBE3A,MAT1A |
| transketolase activity | TKTL2,TKT,TKTB |
Interacting Protein
TKTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TKTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TKTL1.
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References
- Grimm, M; Cetindis, M; et al. Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
- Grimm, M; Hoefert, S; et al. Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 116:E173-E178(2013).
