TINF2
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Official Full Name
TERF1 (TRF1)-interacting nuclear factor 2 -
Overview
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010] -
Synonyms
TINF2;TERF1 (TRF1)-interacting nuclear factor 2;TIN2;DKCA3;TERF1-interacting nuclear factor 2;TRF1-interacting nuclear protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TINF2-4976Z | Recombinant Zebrafish TINF2 | Mammalian Cells | Zebrafish | His |
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| TINF2-1060HCL | Recombinant Human TINF2 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
TINF2 involved in several pathways and played different roles in them. We selected most pathways TINF2 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TINF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Meiotic synapsis | SYCE1,FKBP6,SYCE2,TEX12,SYNE2,STAG1,SYCP1,STAG2,DIDO1,SUN1 |
| Chromosome Maintenance | PANE1,CENPC1,DKC1,SMARCA5,CENPH,RBBP7,RBBP4,CENPO,MIS18BP1,POT1 |
| Cellular Senescence | HIST4H4,HIST1H1A,EED,TERF2,HIST1H1C,TERF2IP,ACD,SUZ12B,ASF1A,RING1 |
| Cell cycle | CEP63,MIS18BP1,CDKN1B,SMC1B,TGFB1,TEX15,OIP5,MAPRE1,TTK,CSNK2A2 |
| Packaging Of Telomere Ends | ACD,POT1,TERF1,POT1A,TERF2 |
| Cellular responses to stress | SUZ12A,CBX6A,SUZ12,HMGA1-RS1,LAMTOR1,DNAJB6,ATG7,HDAC6,UVRAG,RB1CC1 |
| Meiosis | PSMC3IP,STAG1,DIDO1,TERF2,SPO11,SUN1,DMC1,ACD,FKBP6,POT1 |
| DNA Damage/Telomere Stress Induced Senescence | TERF2IP,TERF2,ACD,HIST1H1C,EP400,UBN1,TERF1,ASF1A,POT1A,HIST1H1B |
Protein Function
TINF2 has several biochemical functions, for example, NOT DNA binding,protein binding,telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TINF2 itself. We selected most functions TINF2 had, and list some proteins which have the same functions with TINF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT DNA binding | NFIB,MBD5,XRCC4,HIPK2,SKIL |
| telomeric DNA binding | NCL,TP53BP1,TEN1,TERFA,TERF2,XRCC5,TERT,CDAN1,HNRNPD,OBFC1 |
| protein binding | VAMP8,SKAP1,KLRK1,FDXR,ROR2,GPS1,PLLP,OGG1,AIMP2,NTN1 |
Interacting Protein
TINF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TINF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TINF2.
TERF1;ACD;TERF2
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