THOP1
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Official Full Name
thimet oligopeptidase 1 -
Overview
Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene. -
Synonyms
THOP1;thimet oligopeptidase 1;thimet oligopeptidase;EC 3.4.24.15;Endopeptidase 24.15;EP24.15;MEPD_HUMAN;MP78;THOP1_HUMAN;TOP
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- His
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
THOP1 involved in several pathways and played different roles in them. We selected most pathways THOP1 participated on our site, such as Renin-angiotensin system,African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with THOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | ANPEP,AGTR1B,PRCP,KLK1B26,CPA3,KLK1B22,MRGPRD,ACE2,KLK1B5,NLN |
| African trypanosomiasis | HBB-B2,IL12B,PLCB1,PRKCA,F2RL1,PRKCG,HBB-B1,APOA1,HPR,TLR9 |
Protein Function
THOP1 has several biochemical functions, for example, metal ion binding,metalloendopeptidase activity,peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THOP1 itself. We selected most functions THOP1 had, and list some proteins which have the same functions with THOP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | METAP1,CYP2X9,TAF1B,PATZ1,NR5A5,SHRPRBCK1R,DNAJA2,ZFP39,ZFP827,CRBN |
| peptide binding | ANPEPA,CMA1,ANG,ENPEP,RNPEP,AVPR1B,NPFFR2.1,CCKAR,NPFFR1,OXTRL |
| metalloendopeptidase activity | ADAMTS4,TLL2,ADAM8,UQCRC2B,PMPCB,ECE2,MMP23BB,ADAM33,MMP23B,ADAMTS7 |
| protein binding | PSMA1,C10orf28,NHLRC1,C4orf46,PRCP,CORO1A,TRDN,TNK2,TSEN2,GLIS2 |
Interacting Protein
THOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of THOP1.
Calm1;IKBKE;STK11;MPHOSPH6;CALM1
Resources
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References
- Miners, JS; Verbeek, MM; et al. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. JOURNAL OF NEUROSCIENCE METHODS 167:229-236(2008).
- York, IA; Bhutani, N; et al. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. JOURNAL OF IMMUNOLOGY 177:1434-1443(2006).
