THOC4
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Official Full Name
THO complex 4 -
Overview
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. -
Synonyms
THOC4;THO complex 4;THO complex subunit 4;ALY;ALY/REF;BEF;REF;Ally of AML1 and LEF1;bZIP enhancing factor;THOC 4;THOC-4;Transcriptional coactivator;tho4;OTTHUMP00000218275;ally of AML-1 and LEF-1;bZIP-enhancing factor BEF;transcriptional coactivator Aly/REF
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| THOC4-4704R | Recombinant Rhesus monkey THOC4 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| THOC4-1093HCL | Recombinant Human THOC4 293 Cell Lysate | HEK293 | Human | Non |
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| THOC4-4518R | Recombinant Rhesus Macaque THOC4 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| THOC4-4518R-B | Recombinant Rhesus Macaque THOC4 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
THOC4 involved in several pathways and played different roles in them. We selected most pathways THOC4 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with THOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Processing of Capped Intron-Containing Pre-mRNA | SF3B4,SF3A1,PDCD7,CCAR1,RNPS1,HNRNPA2B1,HNRNPD,HNRNPA0B,TXNL4A,CD2BP2 |
| Herpes simplex infection | SRPK1,JAK2B,IFNA10,NFKB1,BLA,OAS3,TRAF5,H2-Q10,HNRPKL,BMA1 |
| Gene Expression | WDR4,TRMT12,RPP40,ZNF620,TRMT44,NR1D2B,PHF1,CDKAL1,NR2F1A,DNAJC8 |
| RNA Polymerase II Transcription Termination | SLBP,RNPS1,LSM11,SRSF11,CSTF1,CLP1,ZFP473,NUDT21,CSTF2,PAPOLA |
| Cleavage of Growing Transcript in the Termination Region | CSTF3,LSM10,ZFP473,ZNF473,CLP1,NUDT21,SLBP,LSM11,RNPS1,U2AF2 |
| Spliceosome | DDX39B,LSM6,SNRPC,ISY1,HSC70,CWC15,ISY1-RAB43,HSPA2,SRSF2B,DDX5 |
| RNA transport | PABPC1L,PABPC5,NUP155,XPOT,EIF4E1C,GEMIN4,EIF4G2,EIF1AXB,EIF2B1,EIF2B2 |
| RNA Polymerase II Transcription | CCNT2A,CCNT2B,GM3258,ZFP473,CSTF2,CSTF3,NELFE,SLBP,ZNF473,CSTF1 |
Protein Function
THOC4 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THOC4 itself. We selected most functions THOC4 had, and list some proteins which have the same functions with THOC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RTP2,ZCCHC11,RNF165,PPP2R5A,COMT,ZNF302,ATL1,IWS1,CSNK2A2,TBX1 |
| poly(A) RNA binding | DHX16,HIST1H4M,NOP16,BZW1,ZCCHC6,FUS,DUSP14,RPL6,RPS2,GNL2 |
| nucleotide binding | RBM28,TDRD12,PABPC1B,CPEB1,ORC4,U2SURP,MYHC4,RHOT1A,NLRP4B,PAK2A |
Interacting Protein
THOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THOC4.
DDX39B;THOC1;NXF1;THOC5;EIF4A3
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