THEM4

  • Official Full Name

    thioesterase superfamily member 4

  • Overview

    Carboxyl-terminal modulator protein (CTMP) is a negative regulator of Akt and was identified as an Akt binding protein. Akt, also referred to as PKB or Rac, plays a critical role in controlling the balance between survival and apoptosis. This protein kina

  • Synonyms

    THEM4;thioesterase superfamily member 4;C terminal modulator protein;CTMP;C-terminal modulator protein;carboxyl-terminal modulator protein;FLJ27206;MGC29636

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Flag
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    THEM4 involved in several pathways and played different roles in them. We selected most pathways THEM4 participated on our site, such as Activation of AKT2,Adaptive Immune System,CD28 co-stimulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with THEM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downstream signal transduction PEA15A,SPTBN2,IL17RD,PHB,PTPRA,LAMTOR2,DUSP7,FGF20A,FGF18B,DUSP10
    CD28 co-stimulation MAPKAP1,PDPK1A,MAP3K8
    CD28 dependent PI3K/Akt signaling MAPKAP1,PDPK1A,MAP3K8
    Adaptive Immune System CD200R3,AP1B1,ITK,LRR1,AP2S1,GAN,CTSH,CTSS,ARIH2,ASB8
    Activation of AKT2 PDPK1A
    DAP12 interactions SPTBN1,DUSP7,DUSP9,JAK1,HBEGF,CLEC5A,FRS3,IL17RD,NRG4,DUSP6
    DAP12 signaling RASGRP4,FGF18B,SPRED1,IL17RD,WDR83,SPTB,SPNA1,FGF8B,PAQR3B,CSF2RB
    Costimulation by the CD28 family PDPK1A,MAPKAP1,CTLA4,CSK,HLA-DQB2,MAP3K8,BTLA

    Protein Function

    THEM4 has several biochemical functions, for example, palmitoyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THEM4 itself. We selected most functions THEM4 had, and list some proteins which have the same functions with THEM4. You can find most of the proteins on our site.

    Function Related Protein
    palmitoyl-CoA hydrolase activity BAAT,PPT1,ACOT5,ACOT7,ACOT1,ACOT2,GNPAT,ACOT8,THEM5

    Interacting Protein

    THEM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THEM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THEM4.

    AKT1

    Resources

    References

    • Otani, H; Lee, YE; et al. Characterization of p-Hydroxycinnamate Catabolism in a Soil Actinobacterium. JOURNAL OF BACTERIOLOGY 196:4293-4303(2014).
    • Heine, A; Herrmann, G; et al. High resolution crystal structure of Clostridium propionicum beta-alanyl-CoA: ammonia lyase, a new member of the "hot dog fold" protein superfamily. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82:2041-2053(2014).

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