THBS4

  • Official Full Name

    thrombospondin 4

  • Overview

    The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.

  • Synonyms

    THBS4;thrombospondin 4;thrombospondin-4;TSP4

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Wheat Germ
  • CHO
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • His&T7
  • His&GST
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
THBS4-121H Recombinant Human THBS4, GST-tagged Wheat Germ Human GST
Thbs4-120M Active Recombinant Mouse Thbs4, His-tagged CHO Mouse His 27-963 a.a.
THBS4-507H Active Recombinant Human Thrombospondin 4, His-tagged CHO Human His 22-961 a.a.
THBS4-114H Recombinant Human THBS4 protein, T7/His-tagged E.coli Human His&T7 27-961 a.a.
THBS4-8256H Recombinant Human THBS4 protein, His & GST-tagged E.coli Human His&GST Pro644~Cys925
Thbs4-8257M Recombinant Mouse Thbs4 protein, His & GST-tagged E.coli Mouse His&GST Gly662~Leu923
Thbs4-8258R Recombinant Rat Thbs4 protein, His & GST-tagged E.coli Rat His&GST Pro708~Ile963
THBS4-1774HCL Recombinant Human THBS4 cell lysate Human Non
Thbs4-05M Recombinant Mouse Thbs4 Protein, His-tagged HEK293 Mouse His 27-963
Thbs4-2132M Recombinant Mouse Thbs4 Protein, His-tagged E.coli Mouse His Gly662-Leu923
THBS4-523HF Recombinant Full Length Human THBS4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 961 amino acids
THBS4-6447H Recombinant Human THBS4 Protein (Pro644-Leu866), N-GST tagged E.coli Human GST Pro644-Leu866

    Involved Pathway

    THBS4 involved in several pathways and played different roles in them. We selected most pathways THBS4 participated on our site, such as Phagosome,PIK-Akt signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion GRB2B,ITGB8,ITGA3,MAP2K1,VASP,MYL2B,KDRL,PIK3R1,MAPK8A,COL6A1
    Phagosome ITGAM,ATP6AP1B,TUBB2,MHC2DEB,SEC22BB,DYNC1LI1,FCGR3,ATP6V0B,SEC61G,ITGAV
    Malaria VCAM1,THBS1,IL-8,TGFB3,CD40,GYPC,DARC,TLR9,GYPB,HBA2
    PIK-Akt signaling pathway TLR2,TCL1A,GNGT1,PRL,OSM,PTEN,PPP2R5B,KLK1B4,LPAR5,RELA
    ECM-receptor interaction GP6,Npnt,HSPG2,Reln,VTN,SDC4,COL4A3,THBS4A,COL11A2,TNN

    Protein Function

    THBS4 has several biochemical functions, for example, calcium ion binding,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS4 itself. We selected most functions THBS4 had, and list some proteins which have the same functions with THBS4. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity CSF3,CTGF,THPO,PTN,INHBAB,OGN,HDGFRP3,FGF1B,PSPN,FGF20B
    heparin binding CTGFA,LIPI,LIPC,THBS3,ECM2,FGFR2,THBS2,ZFP207,FGF14,LXN
    calcium ion binding RHOT1B,CDH12,CABP4,SERPINB1A,PLCZ1,MAN1A1,EFCAB6,RYR2,FBLN2,CAPN3B
    integrin binding KDR,WISP2,ITGB6,FCER2,NISCH,WISP1A,SEMA7A,THY1,WISP3,CD226
    protein binding RABL2,ATL1,EIF5A,RAB41,TMSB4X,DCAF8,BTK,ABL2,KLF11,BCL2L14

    Interacting Protein

    THBS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS4.

    Atf6

    THBS4 Related Signal Pathway

    Resources

    Research Area

    Notch Family
    Extracellular Matrix Molecules

    References

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