TFEC
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Official Full Name
transcription factor EC -
Overview
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
TFEC;transcription factor EC;bHLHe34;TCFEC;TFECL;Class E basic helix-loop-helix protein 34;hTFEC-L;TFE-C;TFEC protein;TFEC_HUMAN;Transcription factor EC-like;TFEC-L
Recombinant Proteins
- Chicken
- Mouse
- Zebrafish
- Human
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TFEC-1376C | Recombinant Chicken TFEC | Mammalian Cells | Chicken | His |
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| TFEC-16689M | Recombinant Mouse TFEC Protein | Mammalian Cells | Mouse | His |
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| TFEC-3235Z | Recombinant Zebrafish TFEC | Mammalian Cells | Zebrafish | His |
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| TFEC-464H | Recombinant Human TFEC Protein, His-tagged | E.coli | Human | His |
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| TFEC-6027R | Recombinant Rat TFEC Protein | Mammalian Cells | Rat | His |
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| TFEC-5686R | Recombinant Rat TFEC Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TFEC-5686R-B | Recombinant Rat TFEC Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TFEC-9154M | Recombinant Mouse TFEC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TFEC-9154M-B | Recombinant Mouse TFEC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TFEC involved in several pathways and played different roles in them. We selected most pathways TFEC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TFEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TFEC has several biochemical functions, for example, DNA binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TFEC itself. We selected most functions TFEC had, and list some proteins which have the same functions with TFEC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | TP63,RABGAP1,ZFP354C,MCM2,ALS2CR8,VDRB,TOP3A,ESRRGA,ZNF133,GTF2A1L |
| protein dimerization activity | HES6,NPAS4,STK3,HER2,HIF3A,FBXW11,POLR2C,ASCL5,NPAS1,TFE3B |
Interacting Protein
TFEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFEC here. Most of them are supplied by our site. Hope this information will be useful for your research of TFEC.
Resources
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References
- Matsunaga, T; Ishida, T; et al. Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 56:593-601(2002).
- Zimmermann-Belsing, T; Rasmussen, AK; et al. The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor. MOLECULAR AND CELLULAR ENDOCRINOLOGY 188:241-251(2002).
- FISHER, MB; HAYDEN, PJ; et al. FORMATION, CHARACTERIZATION, AND IMMUNOREACTIVITY OF LYSINE THIOAMIDE ADDUCTS FROM FLUORINATED NEPHROTOXIC CYSTEINE CONJUGATES INVITRO AND INVIVO. CHEMICAL RESEARCH IN TOXICOLOGY 6:223-230(1993).
- HAYDEN, PJ; ICHIMURA, T; et al. DETECTION OF CYSTEINE CONJUGATE METABOLITE ADDUCT FORMATION WITH SPECIFIC MITOCHONDRIAL PROTEINS USING ANTIBODIES RAISED AGAINST HALOTHANE METABOLITE ADDUCTS. JOURNAL OF BIOLOGICAL CHEMISTRY 266:18415-18418(1991).
