TFAP4
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Official Full Name
transcription factor AP-4 (activating enhancer binding protein 4) -
Overview
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed 2833704); Hu et al., 1990 (PubMed 2123466)). -
Synonyms
TFAP4;transcription factor AP-4 (activating enhancer binding protein 4);transcription factor AP 4 (activating enhancer binding protein 4);transcription factor AP-4;AP 4;bHLHc41;activating enhancer-binding protein 4;class C basic helix-loop-helix protein 41;transcription factor AP-4 (activating enhancer-binding protein 4);AP-4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TFAP4-1137HCL | Recombinant Human TFAP4 293 Cell Lysate | HEK293 | Human | Non |
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| TFAP4-2133HFL | Recombinant Full Length Human TFAP4 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| TFAP4-2177H | Recombinant Human TFAP4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| TFAP4-2177H-B | Recombinant Human TFAP4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Tfap4-6341M | Recombinant Mouse Tfap4 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
TFAP4 involved in several pathways and played different roles in them. We selected most pathways TFAP4 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | LUM,GAB1,IL12B,CTTN,HSPB2,WNT11,TRP53,CBLB,RRAS2,PPP1R12C |
Protein Function
TFAP4 has several biochemical functions, for example, DNA binding,E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP4 itself. We selected most functions TFAP4 had, and list some proteins which have the same functions with TFAP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNFAIP8L2,ATRX,CYP1A1,IRF2,CDX1,COMMD5,MEIS1B,FAF1,PPM1A,TXN2 |
| transcription regulatory region DNA binding | GABPB1,NKX2-5,PPARG,DLX5,TBP,KLF11,MSX2,TBL1XR1,WNT5A,AHR |
| DNA binding | PURBA,HOXB5B,HOXC13B,SPATA24,ZNF311,ZNF615,HOXA11A,ZFP354C,CXXC1A,ZFP667 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NR1D1,MAX,FOXJ2,MEF2B,POU1F1,BCL11A,TLX1,PPARA,OTX2,SMAD3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TTC6,NR2E1,AKNA,NFIC,HEYL,JUN,EGR2,IRF4,TFE3,NR4A3 |
| E-box binding | C1orf51,AHR,NEUROD2,TWIST1,NEUROG1,CLOCK,NEUROG2,TCF21,MYOG,ASCL2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | THRA,MYF5,SOX9,BHLHE40,MYOD1,LEF1,USF2,SPI1,SRY,PROX1 |
| protein homodimerization activity | FZD1,TENM2,EEA1,GRM6,PFKM,NTRK1,UGT1A4,PVRL1,DGAT2,NR2C1 |
| sequence-specific DNA binding | OTPA,SATB1A,ESRRGA,MNX2A,ARNTL,ZNF397,BCL2,VENTX,GATA2A,CTCFL |
Interacting Protein
TFAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP4.
mdm2_human_probe;GOLGA2;TRAF1;EXOSC8;FBXW11;PRDM5;mdm2_human_gene;AIM2;Fbxw11;Cdkn2aip;Kctd5
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