TERF2
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Official Full Name
telomeric repeat binding factor 2 -
Overview
Binds the telomeric double-stranded 5-TTAGGG-3 repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5-TTAGGG-3 repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3 single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. -
Synonyms
TERF2;telomeric repeat binding factor 2;TRBF2;telomeric repeat-binding factor 2;TRF2;telomeric DNA-binding protein;TTAGGG repeat-binding factor 2;telomeric repeat binding protein 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- DDK&Myc
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TERF2-206H | Recombinant Human TERF2 Protein, His-tagged | E.coli | Human | His | Arg144~Gln438 | |
| TERF2-3393H | Recombinant Human TERF2 protein, His-tagged | E.coli | Human | His | 1-251 aa | |
| TERF2-16644M | Recombinant Mouse TERF2 Protein | Mammalian Cells | Mouse | His |
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| TERF2-4671C | Recombinant Chicken TERF2 | Mammalian Cells | Chicken | His |
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| TERF2-1146HCL | Recombinant Human TERF2 293 Cell Lysate | HEK293 | Human | Non |
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| TERF2-01H | Recombinant Human TERF2 Protein, Myc/DDK-tagged | HEK293 | Human | DDK&Myc |
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| TERF2-353H | Recombinant Human TERF2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Terf2-6359M | Recombinant Mouse Terf2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| TERF2-9130M | Recombinant Mouse TERF2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TERF2-9130M-B | Recombinant Mouse TERF2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TERF2 involved in several pathways and played different roles in them. We selected most pathways TERF2 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TERF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | CEBPB,WDR45L,EP400,AMBRA1,NUP35,RNF2,POT1A,EGLN2,EEF1A1,ACD |
| DNA Damage/Telomere Stress Induced Senescence | RAD50,HMGA1-RS1,HIST1H1A,POT1A,POT1,HIST1H1C,ACD,TINF2,HMGA1,ASF1A |
| Cellular Senescence | BMI1A,IGFBP7,MOV10,HIST4H4,MAPKAPK2B,AGO1,TINF2,LMNB1,HIST1H1B,AGO3 |
| Chromosome Maintenance | CENPA,TERF2IP,NPM1,APITD1,ITGB3BP,SMARCA5,CENPI,RUVBL2,CENPW,TINF2 |
| Meiotic synapsis | POT1A,SYCP2,FKBP6,TEX12,SYCE1,POT1,TERF2IP,TERF1,STAG1,SYNE2 |
| Meiosis | DIDO1,SPO11,MSH5,PSMC3IP,SYCE1,MSH4,SYCP2,POT1,MND1,STAG1 |
| Packaging Of Telomere Ends | TINF2,ACD,POT1,POT1A,TERF1 |
| Cell cycle | ORC4,CDC25C,GADD45BA,DHFR,HIST2H3C,YWHAE2,ODF2,NDEL1A,KAT5,PDS5B |
Protein Function
TERF2 has several biochemical functions, for example, double-stranded telomeric DNA binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TERF2 itself. We selected most functions TERF2 had, and list some proteins which have the same functions with TERF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded telomeric DNA binding | TERF1,TERFA,PURA |
| protein binding | SPON2,CLCN1,POLRMT,RAB33B,CTDNEP1,EIF3J,CCDC109A,FCER1G,KIAA1199,KRTAP9-2 |
| telomeric DNA binding | TINF2,TP53BP1,PIF1,HNRNPD,TERT,CDAN1,XRCC5,CTC1,TEN1,SMG6 |
| protein C-terminus binding | NPAT,PIAS3,LIG4,CORO1A,ERCC2,NIPBL,PEX1,IFT52,CAV3,SNF8 |
| protein homodimerization activity | PRPS1L1,NBL1,SYNE1,GSTM7,P2RX7,GSTZ1,ERP29,HINT2,GHR,ERBB4 |
Interacting Protein
TERF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TERF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TERF2.
TERF2IP;BLM
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References
- Gao, JJ; Roy, S; et al. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. ENVIRONMENTAL RESEARCH 136:462-469(2015).
- Gilchrist, GC; Kurjanowicz, P; et al. Telomere Length and Telomerase Activity in Bovine Pre-implantation Embryos In Vitro. REPRODUCTION IN DOMESTIC ANIMALS 50:58-67(2015).
