TENC1
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Official Full Name
tensin like C1 domain containing phosphatase (tensin 2) -
Overview
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. -
Synonyms
TENC1;tensin like C1 domain containing phosphatase (tensin 2);tensin like C1 domain containing phosphatase;tensin-like C1 domain-containing phosphatase;C1 TEN;KIAA1075;tensin 2;TNS2;tensin-2;tensin like C1 domain-containing phosphatase;C1 domain
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TENC1-16638M | Recombinant Mouse TENC1 Protein | Mammalian Cells | Mouse | His |
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| TENC1-9126M | Recombinant Mouse TENC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TENC1-9126M-B | Recombinant Mouse TENC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TENC1 involved in several pathways and played different roles in them. We selected most pathways TENC1 participated on our site, such as PodNet: protein-protein interactions in the podocyte,XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with TENC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| XPodNet - protein-protein interactions in the podocyte expanded by STRING | CHD1L,FRAS1,GAB3,GJB6,RAVER1,OASL2,ARHGAP33,CDC42EP5,O3far1,ZFP423 |
| PodNet: protein-protein interactions in the podocyte | DDN,LIMS2,SDK1,FAM65A,CMIP,FRAS1 |
Protein Function
TENC1 has several biochemical functions, for example, 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity,IDP phosphatase activity,JUN kinase phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TENC1 itself. We selected most functions TENC1 had, and list some proteins which have the same functions with TENC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/threonine phosphatase activity | SACM1L,PXYLP1,CTDSPL2B,SACM1LB,DUSP19,DUSP1,DUSP2,SACM1LA,CTDSPL2A,NT5DC3 |
| inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity | SACM1LA,PTPRQ,CTDSPL2A,SGPP2,NT5DC3,SACM1L,CTDSPL2B,ITPK1,SACM1LB,PXYLP1 |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | SACM1L,MTMR2,CTDSPL2A,CTDSPL2B,MTMR3,MTMR1B,PXYLP1,SACM1LA,SGPP2,MTMR1 |
| inositol bisphosphate phosphatase activity | PTPRQ,SGPP2,INPP5K,SACM1LB,NT5DC3,CTDSPL2B,SACM1LA,SACM1L,PXYLP1,CTDSPL2A |
| inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity | SACM1LA,CTDSPL2A,SACM1LB,SGPP2,CTDSPL2B,PXYLP1,NT5DC3,PTPRQ,SACM1L |
| inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity | CTDSPL2A,SACM1LB,PTPRQ,SACM1L,ITPK1,SGPP2,PXYLP1,CTDSPL2B,SACM1LA,NT5DC3 |
| kinase binding | LDHB,BTG1,PER3,STUB1,HPCA,SGOL1,DLG1,LDHA,RB1,JAKMIP2 |
| phosphoprotein phosphatase activity | CTDNEP1,DUSP22A,PPM1LA,DUSP26,PPP3CC,DUSP28,PPP2CA,DUSP9,ACP2,PTPRK |
| inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity | ITPK1,PXYLP1,SACM1LA,CTDSPL2A,SACM1LB,CTDSPL2B,SGPP2,NT5DC3,SACM1L,PTPRQ |
Interacting Protein
TENC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TENC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TENC1.
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References
- Karere, GM; Glenn, JP; et al. Identification of candidate genes encoding an LDL-C QTL in baboons. JOURNAL OF LIPID RESEARCH 54:1776-1785(2013).
- Uchio-Yamada, K; Sawada, K; et al. Tenc1-Deficient Mice Develop Glomerular Disease in a Strain-Specific Manner. NEPHRON EXPERIMENTAL NEPHROLOGY 123:22-33(2013).
- Dieterich, LC; Mellberg, S; et al. Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGF beta 2 in vascular abnormalization. JOURNAL OF PATHOLOGY 228:378-390(2012).
- Chen, LH; Liu, CD; et al. H-1, N-15 and C-13 chemical shift assignments of the SH2 domain of human tensin2 (TENC1). BIOMOLECULAR NMR ASSIGNMENTS 5:211-214(2011).
