TCTN2
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Official Full Name
tectonic family member 2 -
Overview
This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TCTN2;tectonic family member 2;C12orf38, chromosome 12 open reading frame 38;tectonic-2;FLJ12975;Meckel syndrome;type 8;MKS8;TECT2;C12orf38
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCTN2-3168H | Recombinant Human TCTN2, His-tagged | E.coli | Human | His | 351-697aa | |
| TCTN2-16596M | Recombinant Mouse TCTN2 Protein | Mammalian Cells | Mouse | His |
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| TCTN2-5996R | Recombinant Rat TCTN2 Protein | Mammalian Cells | Rat | His |
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| TCTN2-1159HCL | Recombinant Human TCTN2 293 Cell Lysate | HEK293 | Human | Non |
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| Tctn2-1417M | Recombinant Mouse Tctn2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| TCTN2-5655R | Recombinant Rat TCTN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| TCTN2-5655R-B | Recombinant Rat TCTN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TCTN2-9099M | Recombinant Mouse TCTN2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TCTN2-9099M-B | Recombinant Mouse TCTN2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TCTN2 involved in several pathways and played different roles in them. We selected most pathways TCTN2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,G2/M Transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | GINS1,PLK4,CEP57,HIST2H3C,CEP63,KIF2B,SET,CEP152,CLASP1A,SETB |
| Mitotic G2-G2/M phases | TUBG2,NUMA1,CDK11A,LIN52,CDK11B,TUBGCP4,BORA,TUBGCP5,LIN9,TUBGCP2 |
| Regulation of PLK1 Activity at G2/M Transition | BORA |
| G2/M Transition | CEP152,CEP72,ODF2B,CEP164,LIN37,CCP110,CEP57,CDK11A,DCTN2,SDCCAG8 |
| Cell cycle | NDEL1A,TGFB1,WRAP53,ODF2B,PIANP,SGOL1,DYRK1A,CLASP1,BANF1,CDKN1BB |
| PLK1 signaling events | BORA,ECT2,SPC24,TPX2,NDC80,ERCC6L,TPT1,PLK1S1 |
Protein Function
TCTN2 has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCTN2 itself. We selected most functions TCTN2 had, and list some proteins which have the same functions with TCTN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | DLG1,RCC2,CCNB3,TSKS,EEF1A1,BCAR1,CACNB3,CNTLN,RNF138,RAB8A |
| protein binding | MZF1,BOP1,GHITM,MOXD1,IL4R,KANSL2,FNBP4,NQO1,NEIL2,CSTF2T |
Interacting Protein
TCTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCTN2.
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References
- Katinas, L; Crisci, JV; et al. Trans-oceanic dispersal and evolution of early composites (Asteraceae). PERSPECTIVES IN PLANT ECOLOGY EVOLUTION AND SYSTEMATICS 15:269-280(2013).
- Lotfy, HI; et al. Active concomitant counterclockwise rotation and northwards translation of Africa during the Albian-Campanian time: A paleomagnetic study on the Wadi Natash alkaline volcanic province (104-78 Ma), South Eastern Desert, Egypt. PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY 310:176-190(2011).
