TDP2

  • Official Full Name

    tyrosyl-DNA phosphodiesterase 2

  • Overview

    This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

  • Synonyms

    EAP2;AD022;TTRAP;MGC9099;dJ30M3.3;MGC111021;RP1-30M3.3;tyrosyl-DNA phosphodiesterase 2;EAPII;OTTHUMP00000016091;OTTHUMP00000016092;ETS1-associated protein 2;ETS1-associated protein II;tyr-DNA phosphodiesterase 2;5"-Tyr-DNA phosphodiesterase;5"-tyrosyl-DNA phosphodiesterase;TRAF and TNF receptor associated protein;TRAF and TNF receptor-associated protein;TDP2;tyrosyl-DNA phosphodiesterase 2

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
TDP2-16603M Recombinant Mouse TDP2 Protein Mammalian Cell Mouse His
TDP2-4713C Recombinant Chicken TDP2 Mammalian Cell Chicken His
TDP2-5999R Recombinant Rat TDP2 Protein Mammalian Cell Rat His
TDP2-7580H Recombinant Human TDP2, His-tagged E.coli Human His 1-362aa
TDP2-664HCL Recombinant Human TTRAP 293 Cell Lysate HEK293 Human Non
TDP2-5658R Recombinant Rat TDP2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
TDP2-5658R-B Recombinant Rat TDP2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Tdp2-6348M Recombinant Mouse Tdp2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
TDP2-6706H Recombinant Human TDP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
TDP2-9104M Recombinant Mouse TDP2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TDP2-9104M-B Recombinant Mouse TDP2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TDP2 involved in several pathways and played different roles in them. We selected most pathways TDP2 participated on our site, such as CD40/CD40L signaling,DNA Double-Strand Break Repair,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CD40/CD40L signaling MYC,JAK3
    DNA Repair USP43A,YY1,EME2,COPS5,ZNF830,FAM175A,BARD1,COPS4,RHNO1,KIAA1530
    DNA Double-Strand Break Repair BAZ1B,RNF168,POLD3,KDM4A,TIMELESS,TDP1,PAXIP1,BRE,BRCC3,EME1
    Nonhomologous End-Joining (NHEJ) TDP1,RIF1,PAXIP1,TDP2B

    Protein Function

    TDP2 has several biochemical functions, for example, 5-tyrosyl-DNA phosphodiesterase activity,magnesium ion binding,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDP2 itself. We selected most functions TDP2 had, and list some proteins which have the same functions with TDP2. You can find most of the proteins on our site.

    Function Related Protein
    manganese ion binding MTPAP,PEPD,PPM1NB,NUDT7,DYRK2,FAM20C,SOD2,ATP2C1,ABL2,PPM1AA
    5-tyrosyl-DNA phosphodiesterase activity TDP2B
    transcription corepressor activity MNT,NR0B2A,GPS2,CSDA,SSX1,HEYL,ZFPM1,TAF9B,FOXP3,PPP1R13L
    protein binding ZMYND11,SNAI2,RPS25,NUBP2,SYNGR1,PRC1,MOV10,SCG2,ZKSCAN5,KCNJ5
    nuclease activity RNASEL4,RAG1,CNOT6,RNASEL2,EXO5,DOM3Z,DNA2,USB1,RNASEKA,EAR2
    magnesium ion binding SIK3,CIB3,PGM5,PPM1A,ATP8B1,IDH3A,ABL2,ABL1,NUDT3,S100P
    single-stranded DNA binding POLR2GL,HSPD1,FUBP1,SETMAR,ERCC5,FBXO18,CDAN1,HNRNPA1,RTF1,RPA3

    Interacting Protein

    TDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDP2.

    SRPK2;DLX3;SKIL;ETS1;PSEN1;ATXN1;JAM2;RAB11A;SMAD3;TAP1;ATP5G2;EPS8;MAPK6;q81xc2_bacan;AKAP9;C2orf88;SNX13

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