Tcrg
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Official Full Name
T-cell receptor gamma chain -
Overview
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. -
Synonyms
TCRG;T-cell receptor gamma chain;T cell antigen receptor gamma subunit;T cell rearranging gene gamma;T cell receptor gamma locus;T cell receptor gamma v region;tarp included;tcrg alternate reading frame protein included;TCRGV1S1;TCRGV2S1;TCRGV3S1;TCRGV5S3
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Involved Pathway
Tcrg involved in several pathways and played different roles in them. We selected most pathways Tcrg participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Tcrg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
Tcrg has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Tcrg itself. We selected most functions Tcrg had, and list some proteins which have the same functions with Tcrg. You can find most of the proteins on our site.
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Interacting Protein
Tcrg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tcrg here. Most of them are supplied by our site. Hope this information will be useful for your research of Tcrg.
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References
- Jiang, QP; Liu, SY; et al. CD20-positive NK/T-cell lymphoma with indolent clinical course: report of case and review of literature. DIAGNOSTIC PATHOLOGY 7:-(2012).
- Moore, PF; Affolter, VK; et al. Canine epitheliotropic cutaneous T-cell lymphoma: an investigation of T-cell receptor immunophenotype, lesion topography and molecular clonality. VETERINARY DERMATOLOGY 20:569-576(2009).
