TCRB
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Official Full Name
T cell receptor beta chain -
Overview
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes several trypsinogen genes. -
Synonyms
TCRB;T cell receptor beta chain;Tib;TCRbeta
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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Involved Pathway
TCRB involved in several pathways and played different roles in them. We selected most pathways TCRB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TCRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
TCRB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TCRB itself. We selected most functions TCRB had, and list some proteins which have the same functions with TCRB. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
TCRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCRB here. Most of them are supplied by our site. Hope this information will be useful for your research of TCRB.
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References
- Han, A; Glanville, J; et al. Linking T-cell receptor sequence to functional phenotype at the single-cell level. NATURE BIOTECHNOLOGY 32:684-+(2014).
- Pullagurla, SR; Witek, MA; et al. Parallel Affinity-Based Isolation of Leukocyte Subsets Using Microfluidics: Application for Stroke Diagnosis. ANALYTICAL CHEMISTRY 86:4058-4065(2014).
