TCP1
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Official Full Name
t-complex 1 -
Overview
T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene. -
Synonyms
TCP1;t-complex 1;T-complex protein 1 subunit alpha;CCT1;Ccta;D6S230E;tailless complex polypeptide 1;T-complex protein 1, alpha subunit;CCT-alpha;TCP-1-alpha
Recombinant Proteins
- Cynomolgus
- Chicken
- Mouse
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TCP1 involved in several pathways and played different roles in them. We selected most pathways TCP1 participated on our site, such as Assembly of the primary cilium,Association of TriC/CCT with target proteins during biosynthesis,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | BBS5,RHOL,IFT74,MKS1,CSNK1E,CP110,ODF2,RAB3IP,TTC26,DYNLL2B |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | PFDN4,VBP1,CCT3,CCT8,CCT7,TUBB4A,CCT6A,CCT5,PFDN5,TUBB4B |
| Association of TriC/CCT with target proteins during biosynthesis | NOP56,FBXW4,CCT2,CCT4,CCT8,CCT7,CCT3,FBXW5,FBXW2,KIFC3 |
| Folding of actin by CCT/TriC | CCT5,CCT6A,CCT2,CCT4,CCT8,CCT7,CCT3 |
| Cargo trafficking to the periciliary membrane | LZTFL1,CCT4,EXOC3,BBS7,BBS1,SETD6,CNGA2,ARF4,EXOC1,BBS12 |
| Chaperonin-mediated protein folding | TUBA3D,FBXW4,CCT6A,FBXW9,PFDN4,CCT7,FBXL5,TUBB4B,PFDN5,NOP56 |
| BBSome-mediated cargo-targeting to cilium | LZTFL1,PROL1,BBS2,BBS9,BBS10,RAB3IP,TTC8,CCT4,BBS7,CCT8 |
| Formation of tubulin folding intermediates by CCT/TriC | CCT5,TUBA3D,CCT8,TUBB4B,CCT2,CCT7,CCT6A,TUBA1B,TUBB4A,CCT3 |
Protein Function
TCP1 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCP1 itself. We selected most functions TCP1 had, and list some proteins which have the same functions with TCP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | POU5F1,GRIK2,JKAMP,LC3,HSPA8,MC4R,LRPPRC,GSK3B,UBE2G1A,FLJ11011L |
| unfolded protein binding | CHAF1B,CRYAA,HSP26,TOR1A,PFDN5,LMAN1,APCS,NDUFAF1,TBCA,HSP90AA1.1 |
| ATP binding | TOP2B,PAK2,STK30,HELLS,GLUL,C22orf28,GC3,VRK2,ABCB3L1,FARSA |
| protein binding | STK25,SMCR7,VPS28,TTI1,DCBLD2,PPP1R8,WDR34,ATL1,VEGFA,SYT4 |
| poly(A) RNA binding | NSUN5,LSM6,REXO4,GLRX3,PRPF8,MTERF,YTHDF2,AKAP8L,GTL3,NUSAP1 |
Interacting Protein
TCP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCP1.
PPP2CA;PPP4C;PPP2CB;OLR1;STRN3;ILK
Resources
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References
- Inoue, Y; Aizaki, H; et al. Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein. VIROLOGY 410:38-47(2011).
- Fijak, M; Zeller, T; et al. Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic marker for low-grade testicular inflammation. HUMAN REPRODUCTION 29:2382-2392(2014).
