TCOF1
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Official Full Name
Treacher Collins-Franceschetti syndrome 1 -
Overview
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TCOF1;Treacher Collins-Franceschetti syndrome 1;treacle protein;treacle;MFD1;TCOF 1;TCOF_HUMAN;Treacher Collins syndrome protein;OTTHUMP00000160560;OTTHUMP00000224041;OTTHUMP00000224042;OTTHUMP00000224043;OTTHUMP00000224077;OTTHUMP00000227678;OTTHUMP00000231643;nucleolar trafficking phosphoprotein;TCS1
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCOF1-2014C | Recombinant Chicken TCOF1 | Mammalian Cells | Chicken | His |
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| TCOF1-31607TH | Recombinant Human TCOF1 | Wheat Germ | Human | Non | 81 amino acids |
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| TCOF1-32H | Recombinant Human TCOF1 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| TCOF1-4655R | Recombinant Rhesus monkey TCOF1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TCOF1-1170HCL | Recombinant Human TCOF1 293 Cell Lysate | HEK293 | Human | Non |
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| TCOF1-10H | Recombinant Human TCOF1 protein, His-tagged | HEK293 | Human | His | Tyr29-Trp97 |
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| TCOF1-3200HFL | Recombinant Full Length Human TCOF1 protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| TCOF1-4471R | Recombinant Rhesus Macaque TCOF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TCOF1-4471R-B | Recombinant Rhesus Macaque TCOF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Tcof1-6342M | Recombinant Mouse Tcof1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
TCOF1 involved in several pathways and played different roles in them. We selected most pathways TCOF1 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCOF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | GNL3,NOP56,NHP2L1A,IMP3,REX1,NOL6,SMFN,CIRH1A,NXT2,WDR36 |
Protein Function
TCOF1 has several biochemical functions, for example, poly(A) RNA binding,protein binding,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCOF1 itself. We selected most functions TCOF1 had, and list some proteins which have the same functions with TCOF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ORC4L,KITLG,NRIP3,TIRAP,ATP2A1,PIH1D3,UBXN4,AZI2,RWDD3,RP9 |
| poly(A) RNA binding | APEH,FASTKD1,DHX16,GANAB,PPIA,MDH2,C1orf35,ALG13,UBE2L3,SLC3A2 |
| transporter activity | MUP3,ABCA5,TAP2,ATP6V1C1,DYF-1,NUP153,SLC5A6B,ABCA7,AP1S2,HIAT1A |
Interacting Protein
TCOF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCOF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCOF1.
ARRB2;ARRB1;SRPK2;TTC4;WDR48;USP44;TM9SF1;MED19;RASSF9;ESR1;TOP1;CSNK2A2;CDK2;BECN1
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