TCIRG1
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Official Full Name
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -
Overview
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis. -
Synonyms
TCIRG1;T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3;T cell, immune regulator 1 , T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3 , T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3;V-type proton ATPase 116 kDa subunit a isoform 3;a3;Atp6i;ATP6N1C;ATP6V0A3;OC 116;OC116;T cell immune response cDNA 7;TIRC7;Atp 6i;ATPase H+ transporting 116kD;OC 116 kDa;OC 116kDa;OPTB 1;OPTB1;Osteoclastic proton pump 116 kDa subunit;Specific 116 kDa vacuolar proton pump subunit;Stv 1;Stv1;T cell immune regulator 1;T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A;T cell immune regulator 1 ATPase H+ transporting lysosomal V0 subunit A3;T cell immune response cDNA7 protein;TCIRG 1;TIRC 7;V ATPase 116 kDa;V ATPase 116 kDa isoform a3;Vacuolar proton translocating ATPase 116 kDa subunit A;Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3;Vph 1;Vph1;OC-116 kDa;V-ATPase 116-kDa;OTTHUMP00000235794;OTTHUMP00000235863;T-cell immune response cDNA 7;ATPase, H+ transporting, 116kD;V-type proton ATPase 116 kDa subunit a;OC-116kDa
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCIRG1-6287C | Recombinant Chicken TCIRG1 | Mammalian Cell | Chicken | His |
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| TCIRG1-1175HCL | Recombinant Human TCIRG1 293 Cell Lysate | HEK293 | Human | Non |
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| TCIRG1-1176HCL | Recombinant Human TCIRG1 293 Cell Lysate | HEK293 | Human | Non |
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| TCIRG1-2753H | Recombinant Human TCIRG1 Protein, His-tagged | E.coli | Human | His | Arg49-Val348 |
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Involved Pathway
TCIRG1 involved in several pathways and played different roles in them. We selected most pathways TCIRG1 participated on our site, such as Collecting duct acid secretion,Epithelial cell signaling in Helicobacter pylori infection,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCIRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ion channel transport | TTYH1,TRPM6,WNK1,ATP7B,ANO1,TRPC5A,TRPC4APB,TRPC4APA,TRPC4,FXYD7 |
| Metabolic pathways | UGT8A,PGM3,SUCLA2,AOC2,CYP4A10,MTHFS,ATP6V0E,GCSH,HK1,POLR1D |
| Collecting duct acid secretion | ATP6V1E2,ATP6V1B2,ATP6V0A2,ATP6V1E1,ATP6V0E1,ATP6V0A4,ATP6V1F,ATP6V1G3,ATP6V0D1,Car2 |
| Iron uptake and transport | FTH1B,TFA,FTH1A,LCN2,ABCG2D,TFR1B,ATP6V1G3,SLC46A1,MFSD7B,FLVCR1 |
| Immune System | OASL,TXNIP,PELI1,CTS7,CASPB,BTR09,IFIT8,UBE2F,PAG1,WASF2 |
| Insulin receptor recycling | ATP6V1G3 |
| Lysosome | CTSSA,AGA,ASAH1B,SCARB2,GGA1,CD63,CD164,HEXB,GLA,ATP6AP1B |
| Epithelial cell signaling in Helicobacter pylori infection | F11R,ATP6V0E1,TJP1,ATP6V1E1,ATP6V1C1,MAPK10,MAPK12,CDC42,ATP6V0C,MAPK13 |
Protein Function
TCIRG1 has several biochemical functions, for example, ATPase binding,proton-transporting ATPase activity, rotational mechanism,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCIRG1 itself. We selected most functions TCIRG1 had, and list some proteins which have the same functions with TCIRG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proton-transporting ATPase activity, rotational mechanism | ATP6V1AA,ATP6V1A,ATP6V1E1B,ATP6V0E,ATP6V1F,ATP6V0B,ATP6V0CB,ATP6V1B2,ATP6V0CA,ATP6V0A1B |
| ATPase binding | UBXN1,TOR1AIP1,FXYD7,SVIP,WFS1,SLC26A9,NHP2L1,NR1H2,ATP1B1,DERL1 |
| transporter activity | SYPA,SLC12A5B,FABP1A,ABCB8,FABP11B,HIAT1,SLC4A2B,ATP5B,ATP5D,FABP7B |
Interacting Protein
TCIRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCIRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCIRG1.
KCNK1;TERF1;SYNCRIP;BAG6;SORT1;GOLT1B
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