TCF7L2
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Official Full Name
transcription factor 7-like 2 (T-cell specific, HMG-box) -
Overview
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene. -
Synonyms
TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF4;transcription factor 7-like 2;TCF 4;hTCF-4;T-cell factor 4;T-cell factor-4 variant A;T-cell factor-4 variant B;T-cell factor-4 variant C;T-cell factor-4 variant D;T-cell facto
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TCF7L2-3308H | Recombinant Human TCF7L2 protein, His-tagged | E.coli | Human | His | 1-355 aa | |
| TCF7L2-4511C | Recombinant Chicken TCF7L2 | Mammalian Cells | Chicken | His |
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| TCF7L2-8855Z | Recombinant Zebrafish TCF7L2 | Mammalian Cells | Zebrafish | His |
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| TCF7L2-1177HCL | Recombinant Human TCF7L2 293 Cell Lysate | HEK293 | Human | Non |
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| TCF7L2-2068H | Recombinant Human TCF7L2 Protein (1-456 aa), His-tagged | E.coli | Human | His | 1-456 aa |
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Involved Pathway
TCF7L2 involved in several pathways and played different roles in them. We selected most pathways TCF7L2 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | TRP53,NFATC3,WNT2B,WNT7B,SERPINF1,CCND3,SFRP2,CTBP2A,FZD2,CCND2A |
| Colorectal cancer | ARAF,BAX,MSH3,RAC3,MAPK3,PIK3CA,SMAD2,AKT1,KRAS,RAC2 |
| Basal cell carcinoma | Fzd4,WNT3A,FZD1,FZD10,FZD9,GSK3B,TCF7,TP53,GLI1,FZD3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA4,SLC8A1,CACNG7,ITGAV,DSC2,DMD,ITGA2B,DSP,CACNB4,ACTN2 |
| Hippo signaling pathway | APC2,WNT16,PARD6B,MPP5,CTGF,DLG3,TCF7,AXIN1,TEAD3,NKD1 |
| Thyroid cancer | TRP53,CDH1,RXRG,HRAS,MAPK1,RXRB,NCOA4,MAP2K1,TP53,PPARG |
| Melanogenesis | EDNRBA,GNAI2B,CAMK2A,WNT4,MITFB,PLCB1,RAF1,WNT5A,CAMK2B,PRKCB |
| Acute myeloid leukemia | PIK3R3,IKBKB,AKT2,PIK3R2,MYC,RPS6KB2,EIF4EBP1,SPI1,MAP2K2,CCND1 |
| Endometrial cancer | TCF7,TRP53,PIK3CG,AXIN2,CASP9,CDH1,PIK3CB,CCND1,SOS1,TP53 |
Protein Function
TCF7L2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7L2 itself. We selected most functions TCF7L2 had, and list some proteins which have the same functions with TCF7L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| armadillo repeat domain binding | LEF1,CHD8,CNOT1,STRN4,STRN,AXIN1,CTNNBIP1,AXIN2,CALCOCO1 |
| sequence-specific DNA binding | PRDM5,BARHL1B,HOXB4,HOXB4A,DBX1,VDR,HOXB1B,CEBPG,CSRNP3,HLF |
| chromatin binding | JMJD5,MSH6,NOC3L,POLG,RUNX2,TOX3,BRD4,SP140,TP53,MED12 |
| beta-catenin binding | FAM123B,PTPRJ,NUMB,TBL1XR1,ESR1,DACT3,CXADR,C,SLC9A3R1,GSK3B |
| RNA polymerase II repressing transcription factor binding | MTA1,BBS1,MKKS,DMAP1,BBS7,BBS10,STAT3,MTA2,TBP,RBPJ |
| protein binding | ZMYM2,IRF3,FAM109B,DTNA,NFIL3,RG9MTD1,PLLP,TBRG4,MEPE,GTF2E1 |
| gamma-catenin binding | FER,PTBP3,DSG1A,DSG1,Fert2,APC2,CDH1,PTPRJ,CDH2,CTNNA1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF257,ZNF395,GLI2,ELK1,NR1D1,KLF5,ZBTB7A,MED8,BSX,MAFB |
| transcription factor binding | NAB1,RNF222,NKX2-5,PSMC5,TFDP2,PARD6A,FHL2,TNFRSF10A,TAF12,KEAP1 |
Interacting Protein
TCF7L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7L2.
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References
- Rulifson, IC; Majeti, JZ; et al. Inhibition of secreted frizzled-related protein 5 improves glucose metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 307:E1144-E1152(2014).
- Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).
