TBXA2R
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Official Full Name
thromboxane A2 receptor -
Overview
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TBXA2R;thromboxane A2 receptor;Prostanoid TP receptor;TP receptor;TXA2 R;TXA2R;TXA2-R;BDPLT13
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- Mus musculus
- Chlorocebus Aethiops
- Bovine
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
TBXA2R involved in several pathways and played different roles in them. We selected most pathways TBXA2R participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBXA2R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet activation | PIK3CD,GNAI1,FGB,PIK3R1,ARHGAP35,VAMP8,ORAI1,MAPK13,AKT1,PIK3CA |
| Calcium signaling pathway | ADRB2A,GRIN1B,P2RX4B,TACR1,CAMK2A,CACNA1G,PTGFR,ITPKA,HRH1,GNAQ |
| Neuroactive ligand-receptor interaction | TRHR,EDNRAA,TAAR9,ADCYAP1R1A,HRH1,ADORA1,TRHRB,GRM2,TAAR8B,TAAR10C |
Protein Function
TBXA2R has several biochemical functions, for example, guanyl-nucleotide exchange factor activity,protein binding,thromboxane A2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBXA2R itself. We selected most functions TBXA2R had, and list some proteins which have the same functions with TBXA2R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thromboxane A2 receptor activity | TBXAS1 |
| protein binding | RNF180,RCN2,AP5S1,PPP5C,C18orf56,CDKN1C,MKL1,SMAD4,CSNK1G1,IP6K2 |
| guanyl-nucleotide exchange factor activity | RPGR,NET1,RASGRP1,PTGIR,ARHGEF39,VAV3,SH2D3A,ARFGEF2,ITSN1,FGD2 |
Interacting Protein
TBXA2R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBXA2R here. Most of them are supplied by our site. Hope this information will be useful for your research of TBXA2R.
PRDX4;GPRASP1;q81y32_bacan;CANX
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References
- Lin, H; Li, HF; et al. Thromboxane A2 Mediates Iron-Overload Cardiomyopathy in Mice Through Calcineurin-Nuclear Factor of Activated T Cells Signaling Pathway. CIRCULATION JOURNAL 77:2586-2595(2013).
- Himmerich, H; Schmidt, L; et al. Impact of Clozapine, N-Desmethylclozapine and Chlorpromazine on Thromboxane Production in Vitro. MEDICINAL CHEMISTRY 8:1032-1038(2012).
