TBX3
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Official Full Name
T-box 3 -
Overview
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. -
Synonyms
TBX3;T-box 3;ulnar mammary syndrome , UMS;T-box transcription factor TBX3;TBX3 ISO;XHL;T-box protein 3;bladder cancer related protein XHL;UMS;TBX3-ISO
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
TBX3 involved in several pathways and played different roles in them. We selected most pathways TBX3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | RAF1,SMAD9,PIK3CG,OTX1,PIK3R3,MEIS1,AXIN1,WNT9A,SETDB1,BMPR2 |
Protein Function
TBX3 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX3 itself. We selected most functions TBX3 had, and list some proteins which have the same functions with TBX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | PROX1A,BCL11A,ZFP536,SP3,MZF1,MYPOP,TFAP2C,ATF7,NR2E1,HOXA2 |
| RNA polymerase II activating transcription factor binding | BHLHE40,T,TBX20,POU1F1,LDB1,ZFPM1,TP53BP1,MAD2L2,SIN3A,NCOR1 |
| protein binding | BLMH,IL6ST,EHMT2,EP300,MGST1,EML1,LRRIQ3,BMP4,PLP2,PRKD1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GABPA,KLF17,FOSB,CEBPE,NR2C1,RUNX2,GLI2,JUNBA,FOXI1,PRDM1 |
| sequence-specific DNA binding | KDM6B,ALX4B,USF2,NKX2.4B,VSX1,NFIL3-6,SALL3B,FOXG1A,DLX4,FOXP1A |
| RNA polymerase II transcription factor binding | SMAD4,GSC,GATA6,T,GATA5,GATA1,ATF4,GATA2,GFI1B,MTDH |
Interacting Protein
TBX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX3.
CA8;AES;Dlg4;TOLLIP
Resources
Research Area
Hepatic Progenitor Cell Transcription FactorsOsteoclast Markers
Cancer Stem Cell Transcription Factors
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Embryonic and Induced Pluripotent Stem Cell Markers
Osteoblast and Osteoclast Markers
Related Services
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References
