TBX1
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Official Full Name
T-box 1 -
Overview
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
TBX1;T-box 1;DGS;TGA;VCF;CAFS;CTHM;DGCR;DORV;VCFS;TBX1C;CATCH22;T-box transcription factor TBX1;brachyury;Testis-specific T-box protein;T-box 1 transcription factor C
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TBX1-9699Z | Recombinant Zebrafish TBX1 | Mammalian Cell | Zebrafish | His |
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| TBX1-415H | Recombinant Human TBX1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| TBX1-5465H | Recombinant Human TBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Tbx1-6318M | Recombinant Mouse Tbx1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
TBX1 involved in several pathways and played different roles in them. We selected most pathways TBX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
TBX1 has several biochemical functions, for example, DNA binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX1 itself. We selected most functions TBX1 had, and list some proteins which have the same functions with TBX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | STAT6,PCGF2,WNT5A,PPARAA,GATA1,FOXG1B,ZNF8,POU4F2,HOXC5A,FOXD2 |
| protein binding | FAM184A,HLCS,RAB23,ANKHD1,CEP55,TGFA,LRRC33,MYOZ1,HORMAD1,RAD54L |
| protein homodimerization activity | CHMP3,PRDX4,GPD1L,SRR,SLC51A,FGFR1,RENBP,TFRC,TCF3A,CREB3L3 |
| sequence-specific DNA binding | PRRX1,FOXP4,CREBZF,NR0B1,JUNBB,GATA1A,NKX2-8,RORB,GLI1,ATF7 |
| DNA binding | HOXB2A,ONECUT1,ZNF557,HIST1H4C,ZFP35,GEN1,HOXA9B,ZFP628,TRERF1,TOX2 |
Interacting Protein
TBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX1.
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References
- Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).
- Kimura, W; Sharkar, MTK; et al. Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. TRANSGENIC RESEARCH 22:659-666(2013).
