TBPL1
-
Official Full Name
TBP-like 1 -
Overview
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes. -
Synonyms
TBPL1;TBP-like 1;TATA box-binding protein-like protein 1;STUD;TLF;TLP;TRF2;21kDa TBP like protein;Second TBP of unique DNA;TATA box binding protein like protein 1;TATA box binding protein-related factor 2;TBP like 1;TBP like protein;TBP related factor 2;TBP-like factor;TBP-like protein 1;TBP-related protein;TBP-related factor 2;21 kDa TBP-like protein;21-kDA TBP-like protein;second TBP of unique DNA protein;TATA box-binding protein-related factor 2;MGC:8389;MGC:9620
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
Involved Pathway
TBPL1 involved in several pathways and played different roles in them. We selected most pathways TBPL1 participated on our site, such as Basal transcription factors,Huntingtons disease,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | SMAD2,BUB3,PPP3CA,TGFBR2,TNF,H2-AB1,NFKB2,EGR1,TBPL2,FOSL1 |
| Herpes simplex infection | IKBKE,EEF1DA,CUL1B,HLA-DRB1,IFIT1,EIF2AK3,PML,UBE2R2,CCL2,CDC34A |
| Basal transcription factors | TAF9B,TAF4B,GTF2H2,GTF2H3-2,TBPL2,TAF12,ERCC3,TAF3,TAF10,GTF2H2C_2 |
| Huntingtons disease | COX6A2,mt-Atp8,COX6B1,DCTN2,COX5A,COX4I2,TFAM,SDHD,EP300,UQCRH |
| Epstein-Barr virus infection | PSMD4,PIK3R3,ITGAL,PTMA,HDAC1,PIK3R5,HDAC4,NEDD4,RELB,XPO1 |
| Viral carcinogenesis | TRAF5,HDAC3,GTF2E1,HDAC9,YWHAH,HIST1H2BE,HIST1H2BD,HIST1H4I,CDK1,SND1 |
Protein Function
TBPL1 has several biochemical functions, for example, DNA binding,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBPL1 itself. We selected most functions TBPL1 had, and list some proteins which have the same functions with TBPL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SMARCAD1,NKX6.3,SCXB,SIX6,MSH2,PPARD,ZNF620,PROX2,IRX5B,TFDP1 |
| transcription coactivator activity | GMEB2,ABT1,RFXAP,TRIP4,NR1I3,NR1H3,RNF4,WWTR1,NR5A1,KAT2B |
| protein binding | PAM,KIF20B,AKT1S1,APITD1,ADRB3,LLGL1,HDAC10,TP53,AP2S1,NEK11 |
Interacting Protein
TBPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBPL1.
GTF2A1;TNNT1;PRNP;GTF2A2;PMVK;PLIN3;RPL10;NDUFA6;RAB35;SLC35F6;PTCD3;ABCF3;IRAK4
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