TBL1Y
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Official Full Name
transducin (beta)-like 1, Y-linked -
Overview
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. -
Synonyms
TBL1Y;transducin (beta)-like 1, Y-linked;F-box-like/WD repeat-containing protein TBL1Y;TBL1;Y-linked;TBL1Y_HUMAN;Transducin (beta) like 1, Y linked;Transducin beta-like 1;Transducin beta-like protein 1Y;Transducin-beta-like protein 1;Transducin-beta-like protein 1, Y-linked;OTTHUMP00000033224;OTTHUMP00000033225;OTTHUMP00000033226
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TBL1Y-4643R | Recombinant Rhesus monkey TBL1Y Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| TBL1Y-1213HCL | Recombinant Human TBL1Y 293 Cell Lysate | HEK293 | Human | Non |
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| TBL1Y-1190H | Recombinant Human TBL1Y Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| TBL1Y-4459R | Recombinant Rhesus Macaque TBL1Y Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TBL1Y-4459R-B | Recombinant Rhesus Macaque TBL1Y Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| TBL1Y-5486H | Recombinant Human TBL1Y Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
TBL1Y involved in several pathways and played different roles in them. We selected most pathways TBL1Y participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBL1Y were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | CCND2A,DKK1,CAMK2A,LRP5,NFATC2,PPP3R2,FZD1,DVL3A,MYCB,RUVBL1 |
Protein Function
TBL1Y has several biochemical functions, for example, DNA binding,chromatin binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBL1Y itself. We selected most functions TBL1Y had, and list some proteins which have the same functions with TBL1Y. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | KCNA3,SKOR2,NR0B2,SNW1,APEX1,SSX3,KLF12,TRIM22,KCNIP3,SIRT1 |
| chromatin binding | RFX4,JMJD5,PROP1,COQ7,MSL1,PARP1,FOSL2,HINFP,RNF2,NSBP1 |
| DNA binding | RAD52,GLIS2,GTF2IRD2,ADNP,DMRT2,LHX8A,PBX1B,NR1D4B,ZNF3,H2AFB1 |
Interacting Protein
TBL1Y has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBL1Y here. Most of them are supplied by our site. Hope this information will be useful for your research of TBL1Y.
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References
- Tagariello, A; Breuer, C; et al. Functional Null Mutations in the Gonosomal Homologue Gene TBL1Y are Associated with Non-Syndromic Coarctation of the Aorta. CURRENT MOLECULAR MEDICINE 12:199-205(2012).
- Tagariell, A; Breuer, C; et al. Functional null mutations in the gonosomal homologue gene TBL1Y associated with sporadic coarctation of the aorta. CLINICAL RESEARCH IN CARDIOLOGY 100:860-860(2011).
