TAS2R38
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Official Full Name
taste receptor, type 2, member 38 -
Overview
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). -
Synonyms
TAS2R38;taste receptor, type 2, member 38;phenylthiocarbamide tasting , PTC;taste receptor type 2 member 38;T2R61;PTC;PTC bitter taste receptor;T2R38;taste receptor type 2 member 61
Recombinant Proteins
- Human
- Mus musculus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pan paniscus
- Papio hamadryas (Hamadryas baboon)
- Hylobates klossii (Kloss's gibbon)
- Pongo Pygmaeus
- Pan troglodytes
- HEK293
- E.coli
- Non
- His
Involved Pathway
TAS2R38 involved in several pathways and played different roles in them. We selected most pathways TAS2R38 participated on our site, such as Taste transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAS2R38 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Taste transduction | GNG3,TAS2R114,TRPM5,TAS2R144,Adcy4,TAS2R136,TAS2R117,TAS2R134,TAS2R124,GNAS |
Protein Function
TAS2R38 has several biochemical functions, for example, bitter taste receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAS2R38 itself. We selected most functions TAS2R38 had, and list some proteins which have the same functions with TAS2R38. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| bitter taste receptor activity | TAS2R40,TAS2R140,TAS2R138,TAS2R144,TAS2R108,TAS2R120,TAS2R3,TAS2R114,TAS2R121,TAS2R118 |
Interacting Protein
TAS2R38 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAS2R38 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAS2R38.
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