TAS2R13
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Official Full Name
taste receptor, type 2, member 13 -
Overview
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. -
Synonyms
TAS2R13;taste receptor, type 2, member 13;taste receptor type 2 member 13;T2R13;TRB3;Taste receptor, family B, member 3;taste receptor family B member 3
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Pan paniscus
- Pan troglodytes
- Pongo Pygmaeus
- Mus musculus
- Papio hamadryas (Hamadryas baboon)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
TAS2R13 involved in several pathways and played different roles in them. We selected most pathways TAS2R13 participated on our site, such as Class C/3 (Metabotropic glutamate/pheromone receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAS2R13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | RXFP2B,NMBA,DNAL4B,OPN5,ARHGAP24,ARHGAP44,USP9,FAM13A,BOC,OR52B4 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | CASR,GPRC6A,TAS2R3,TAS2R16,TAS2R7 |
| Taste transduction | PDE1A,TAS2R20,TRPM5,TAS2R106,TAS1R1,TAS2R117,TAS2R109,Adcy4,TAS2R107,GNB1 |
| G alpha (i) signalling events | POMCB,RGS20,ADRA2B,CCR6,PENK,ADORA1,APPA,OXGR1A.1,GPR18,FPR-RS6 |
| Signaling by GPCR | PRLH,PRKCHB,ARHGEF18A,CCL35.1,PNOC,OPN1LW1,OXTRL,OR10A5,CXCR7B,TAS2R7 |
| GPCR downstream signaling | FGD4A,NPFFR2,CCL27,PENKA,ADRA2A,LPAR1,HCRT,PROKR1A,RGS19,ADRB3 |
| GPCR ligand binding | CCL19A.2,RCA2.1,CCBP2,GPR68,PTH2,GNB5B,SSTR2,CASR,GNB5A,HRH3 |
Protein Function
TAS2R13 has several biochemical functions, for example, bitter taste receptor activity,taste receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAS2R13 itself. We selected most functions TAS2R13 had, and list some proteins which have the same functions with TAS2R13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| bitter taste receptor activity | TAS2R3,TAS2R114,TAS2R108,TAS2R121,TAS2R7,TAS2R137,TAS2R136,TAS2R139,TAS2R40,TAS2R144 |
| taste receptor activity | TAS1R1,TAS2R140,TAS2R108,TAS2R134,TAS2R143,TAS2R3,O3far1,TAS2R7,TAS1R2,TAS2R144 |
Interacting Protein
TAS2R13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAS2R13 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAS2R13.
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References
- Allen, AL; McGeary, JE; et al. Polymorphisms in TRPV1 and TAS2Rs Associate with Sensations from Sampled Ethanol. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:2550-2560(2014).
- Mfuna Endam, L; Filali-Mouhim, A; et al. Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study. INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 4:200-206(2014).
