TARBP1
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Official Full Name
TAR (HIV-1) RNA binding protein 1 -
Overview
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
TARBP1;TAR (HIV-1) RNA binding protein 1;TRM3;TRP185;TRP-185;probable methyltransferase TARBP1;TAR RNA-binding protein 1;TAR RNA loop binding protein;TAR (HIV) RNA binding protein 1;TAR (HIV) RNA-binding protein 1;tRNA methyltransferase 3 homolog;TAR RNA-binding protein of 185 kDa
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Involved Pathway
TARBP1 involved in several pathways and played different roles in them. We selected most pathways TARBP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TARBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
TARBP1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TARBP1 itself. We selected most functions TARBP1 had, and list some proteins which have the same functions with TARBP1. You can find most of the proteins on our site.
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Interacting Protein
TARBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TARBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TARBP1.
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References
- Robinson, JA; et al. beta-Hairpin Peptidomimetics: Design, Structures and Biological Activities. ACCOUNTS OF CHEMICAL RESEARCH 41:1278-1288(2008).
- Jeong, JG; Kim, DS; et al. A Tat-grafted anti-nucleic acid antibody acquires nuclear-localization property and a preference for TAR RNA. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 406:403-407(2011).
