TAL1
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Official Full Name
T-cell acute lymphocytic leukemia 1 -
Overview
T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. -
Synonyms
TAL1;T-cell acute lymphocytic leukemia 1;TCL5;T-cell acute lymphocytic leukemia protein 1;bHLHa17;SCL;Class A basic helix-loop-helix protein 17;OTTHUMP00000009563;OTTHUMP00000009564;Stem cell protein;T cell acute lymphocytic leukemia 1;T cell acute lymphocytic leukemia 1 protein;T cell leukemia/lymphoma 5 protein;T-cell leukemia/lymphoma protein 5;Tal 1;Tal 1 product;TAL 1 protein;TAL-1;TAL1_HUMAN;TCL 5;tal-1 product
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAL1-12439Z | Recombinant Zebrafish TAL1 | Mammalian Cells | Zebrafish | His |
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| TAL1-6904C | Recombinant Chicken TAL1 | Mammalian Cells | Chicken | His |
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| TAL1-1259HCL | Recombinant Human TAL1 293 Cell Lysate | HEK293 | Human | Non |
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| TAL1-2749H | Recombinant Human TAL1 Protein, His-tagged | E.coli | Human | His | Pro29-Arg331 |
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Involved Pathway
TAL1 involved in several pathways and played different roles in them. We selected most pathways TAL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TAL1 has several biochemical functions, for example, E-box binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAL1 itself. We selected most functions TAL1 had, and list some proteins which have the same functions with TAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone deacetylase binding | SP1,HES1,NACC2,RBBP4,MAGEA1,RELA,SIX3,HIC1,HDAC4,GMNN |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | GATA6,NHLH2,EF1,ZNF174,NPAS1,SIM2,ZNF496,KLF11,FOXQ1,NPAS4A |
| protein binding | GRASP,YES1,SERTAD3,SKIL,KRAS,RGS14,MXD1,NPM1,EIF3G,SLC4A1 |
| transcription factor activity, sequence-specific DNA binding | SMAD3B,BACH2,RXRA,ETV5B,ZNF131,RUNX1T1,ELF2B,SOX11B,SP140,SIM1A |
| RNA polymerase II distal enhancer sequence-specific DNA binding | NR5A1,CDX2,RUVBL2,NR1H4,RELA,MIXL1,MSC,POU4F1,H3F3B,ESRRB |
| RNA polymerase II transcription factor binding | HCLS1,NFATC1,SPI1,SMAD4,GATA1A,DHX9,TEAD3,GATA2,TBX20,ZFPM2 |
| chromatin binding | HDAC2,TMPOA,CSNK2B,ACTL6A,NCOA3,CBX4,PRDM13,SP3,MEIS3,ELK4 |
| enzyme binding | POLB,ESR1,NPM2,PRKCD,CD40,CAT,UBE4B,CCDC99,TGFB1,CAD |
| RNA polymerase II regulatory region sequence-specific DNA binding | SP5,NEUROD2,BHLHA15,ZFP583,ATF4,POU3F4,CREB3L4,SKINT8,ATF4B2,ZNF549 |
Interacting Protein
TAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAL1.
TCF3;TCF12;Lmo2;ETS1;RUNX1;CDK9;TRIM33
Resources
Research Area
Hemangioblast MarkersTranscription Factors in the Akt Pathway
Cancer Stem Cell Transcription Factors
Hemangioblast Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Intracellular Signaling Molecules in Angiogenesis
Mesodermal Lineage Markers
Related Services
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References
- Karrman, K; Kjeldsen, E; et al. The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. BRITISH JOURNAL OF HAEMATOLOGY 144:546-551(2009).
- Biggs, JS; Wan, J; et al. Transcription factor binding to a putative double e-box motif represses CYP3A4 expression in human lung cells. MOLECULAR PHARMACOLOGY 72:514-525(2007).
