TAG72
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Official Full Name
Tumor associated Glycoprotein 72 -
Overview
The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas. Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, and pancreatic cells. It is a mucin-like molecule with a molar mass of over 1000 kDa. TAG-72 is a tumor marker and can be measured with radioimmunoassays like CA 72-4, which uses indium (111In) satumomab pendetide and iodine (125I) CC49 monoclonal antibody. This assay has a good specificity for gastric cancer, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment. TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab. -
Synonyms
CA 72.4;TAG 72;Tumor associated Glycoprotein 72;TAG72;OncoScint CR103;Satumomab Pendetide;138955-26-7;Minretumomab;195189-17-4
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Involved Pathway
TAG72 involved in several pathways and played different roles in them. We selected most pathways TAG72 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAG72 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
TAG72 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TAG72 itself. We selected most functions TAG72 had, and list some proteins which have the same functions with TAG72. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
TAG72 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAG72 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAG72.
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References
- Cheng, CM; Tzou, SC; et al. Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System. PLOS ONE 9:-(2014).
- Ding, HM; Carlton, MM; et al. Site Specific Discrete PEGylation of I-124-Labeled mCC49 Fab' Fragments Improves Tumor MicroPET/CT Imaging in Mice. BIOCONJUGATE CHEMISTRY 24:1945-1954(2013).
