TAF6L
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Official Full Name
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor -
Overview
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that;coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the;polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a;channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily;conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as;coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex;assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase;complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is;composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and;differentiation. -
Synonyms
TAF6L;TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor;TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L;TAF6-like RNA polymerase II p300;CBP associated factor associated factor 65 kDa subunit 6L;PAF65 alpha;PAF65A;PCAF associated factor 65 alpha;TAF6 like RNA polymerase II p300/CBP associated factor associated factor 65 kDa subunit 6L
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TAF6L-3106H | Recombinant Human TAF6L, GST-tagged | E.coli | Human | GST | 1-351aa | |
| TAF6L-3364H | Recombinant Human TAF6L protein, His-tagged | E.coli | Human | His | 1-351 aa | |
| TAF6L-7866Z | Recombinant Zebrafish TAF6L | Mammalian Cell | Zebrafish | His |
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| TAF6L-1734HCL | Recombinant Human TAF6L cell lysate | Human | Non |
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Involved Pathway
TAF6L involved in several pathways and played different roles in them. We selected most pathways TAF6L participated on our site, such as Basal transcription factors,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF6L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal transcription factors | GTF2H2C_2,GTF2A1,GTF2A1L,TBPL1,GTF2F2B,TAF13,GTF2F1,TAF7L,GTF2H3,GTF2H2 |
| Chromatin organization | TADA3,ARID5B,MSL1,RBBP5,ELP2,ELP3,KAT6B,PHF21A,KAT7,JMJD6 |
| HATs acetylate histones | ELP2,ANO9A,TADA2B,KAT6A,KAT8,DMAP1,PHF20B,MEAF6,KANSL2,VPS72 |
| Herpes simplex infection | IL12B,PPP1CA,TAF6,HCFC1B,IFNB,EP300,C3,SRSF3,IFNG1-2,TBP |
| Chromatin modifying enzymes | DNMT3A,KAT6A,PADI6,KDM1B,PADI3,JHDM1D,MSL3,RUVBL2,SMARCE1,TADA3 |
Protein Function
TAF6L has several biochemical functions, for example, DNA binding,contributes_to histone acetyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF6L itself. We selected most functions TAF6L had, and list some proteins which have the same functions with TAF6L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | HIST2H2L,HIST1H2AB,ADRA2C,VAPA,BHLHE40,CD3E,H2AFB1,MCL1A,TAF9,ALX4 |
| transcription coactivator activity | NFE2,RXRA,HTATIP2,MYOD1,CREBBP,SMARCA4,KAT2B,NR2F1,CCAR1,JUNBB |
| DNA binding | ZNF454,FANCM,BARHL1A,SP6,ZFP36L3,ZNF367,VDR,RBFOX3,LHX1B,ZFP511 |
| protein binding | NOTCH2,NOTCH2NL,CD300LG,LURAP1,CTNND1,CYFIP2,KIR2DL3,DDO,ADA,TXNDC9 |
| contributes_to histone acetyltransferase activity | TAF10,SUPT3H,TADA1,EPC1,TADA2B,SUPT7L,TADA2A,TAF12,ING3,TEX30 |
Interacting Protein
TAF6L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF6L here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF6L.
TAF9;TAF9B;USP22;STX11;MYOG;KAT2B;CCDC101
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References
- Weake, VM; Swanson, SK; et al. A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression. GENES & DEVELOPMENT 23:2818-2823(2009).
