TAF4
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Official Full Name
Taf4p -
Overview
The basal transcription factor TFIID plays a central role in the regulation of gene expression in Eukaryota and is a large protein complex composed of TATA box-binding protein (TBP) and 14 kinds of TBP-associated factors (TAF). TFIID directly recognizes and binds to different kinds of core promoter elements that localize near the transcription initiation site and forms a scaffold for the other basal transcription factors to assemble. At the same time, it transmits transcriptional activation signal originating from transcription regulating factors to RNA polymerase II. Taf4p is one of the subunits of TFIID and in the case of budding yeast, it is composed of 388 amino acid residues (aa). This protein contains histone folds in its interior and forms TAF octamer with Taf6p, Taf9p and Taf12p. The product was prepared by immunizing rabbit with recombinant protein which was over-expressed in E. coli with a plasmid carrying the N-terminal domain of Taf4p protein (1-200aa) of budding yeast, and purified by chromatography. Using this antiserum in Western blotting, the band of 48 kD corresponding to Taf4p was obtained from the extract of yeast cells. -
Synonyms
TAF4;Taf4p;MPT1;TAF48;TSG2;YMR005W;NP_013718.1;Eukaryota;Fungi;Ascomycota;Saccharomycotina (true yeasts);Taphrinomycotina;Schizosaccharomycetes (fission yeasts);Basidiomycota;Agaricomycotina;Tremellomycetes;Pucciniomycotina;Microbotryomycetes;taf-4;TAF (TBP-associated transcription factor) family;TAF (TBP-associated transcription factor) family member (taf-4);TAF2C;TAF2C1;TAF4A;TAFII 130;TAFII 135;TBP associated factor 4;TBP Associated transcription Factor family member
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Involved Pathway
TAF4 involved in several pathways and played different roles in them. We selected most pathways TAF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
TAF4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TAF4 itself. We selected most functions TAF4 had, and list some proteins which have the same functions with TAF4. You can find most of the proteins on our site.
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Interacting Protein
TAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF4.
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