TADA3
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Official Full Name
transcriptional adaptor 3 -
Overview
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined. -
Synonyms
ADA3;NGG1;hADA3;TADA3L;FLJ20221;FLJ21329;transcriptional adapter 3;STAF54;ADA3 homolog;ADA3-like protein;OTTHUMP00000158554;OTTHUMP00000158555;OTTHUMP00000207467;TADA3;transcriptional adaptor 3
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
TADA3 involved in several pathways and played different roles in them. We selected most pathways TADA3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with TADA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | PRMT7,KDM4D,KDM1A,VPS72,PBRM1,KDM4C,KDM5C,SMARCB1,EPC1,ELP2 |
| HATs acetylate histones | YEATS4,BRD1,KANSL2,ING5B,VPS72,TADA2B,KAT8,ZZZ3,TAF6L,MSL2A |
| Chromatin modifying enzymes | MSL2,SAP30L,MBD3A,SMARCB1A,ASH2L,RBB4L,SUZ12A,KDM7AB,MORF4L1,PADI4 |
Protein Function
TADA3 has several biochemical functions, for example, contributes_to histone acetyltransferase activity,ligand-dependent nuclear receptor binding,ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TADA3 itself. We selected most functions TADA3 had, and list some proteins which have the same functions with TADA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to histone acetyltransferase activity | KAT5,TEX30,TADA1,TAF12,TAF10,SUPT3H,TADA2B,SAP130,TADA2A,TAF9 |
| transcription coactivator activity | NFYC,ARL2BP,NFATC4,KAT2A,JUNBA,EP300,NR1H3,MKL1,VGLL2,NEUROD1 |
| ligand-dependent nuclear receptor transcription coactivator activity | NCOA2,HMGA1-RS1,FGF2,PPARGC1A,PSMC3IP,MED4,USP22,CCAR1,RBM14,ENY2 |
| protein domain specific binding | CNTLN,DBNL,ITGA3,ESRRA,TRIM11,MECP2,CALM,RHOA,MTOR,IRS2 |
| transcription factor activity, sequence-specific DNA binding | NFATC2,HIF1A,KLF2,GLI3,GLI4,ZNF550,MNX1,HOXC6A,DDIT3,ATF5A |
| protein binding | EFNA3,RAP2A,LRDD,U2AF1,DDIT4L,KIF21A,TCEA2,HIST1H2AI,LAMA4,WDTC1 |
| ligand-dependent nuclear receptor binding | NCOA3,SLC30A9,NR1H4,BAZ2A,ISL1,TRIM24,SRA1,NCOA1,SMARCE1,ARID1A |
Interacting Protein
TADA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TADA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TADA3.
CCDC101;CCNC;HEXIM2;KAT2B;USP5;PIAS4;BRCA1;USP22;q5t9k6_human
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